Global patent index - EP 0973390 A1

EP 0973390 A1 2000-01-26 - RETINOID RELATED MOLECULES FOR THE INHIBITION OF ENDOTHELIN-1 OVERPRODUCTION IN DISEASE

Title (en)

RETINOID RELATED MOLECULES FOR THE INHIBITION OF ENDOTHELIN-1 OVERPRODUCTION IN DISEASE

Title (de)

MIT RETINOIDEN VERWANDTE VERBINDUNGEN ZUR HEMMUNG KRANKHAFTER ENDOTHELIN-1-ÜBERPRODUKTION

Title (fr)

MOLECULES LIEES AUX RETINOIDES ET PERMETTANT D'ENRAYER LA SURPRODUCTION D'ENDOTHELINE 1 DANS L'AFFECTION

Publication

EP 0973390 A1 (EN)

Application

EP 98914647 A

Priority

  • US 9807125 W
  • US 4329397 P

Abstract (en)

[origin: WO9846076A1] A method of inhibiting endothelin-1 in a subject comprising administering to the subject an inhibiting amount of a suitable retinoid or retinoid related molecule and a method of treating pain and diseases associated with the presence of increased levels of endothelin-1in subjects comprising administering an endothelin-1 inhibiting amount of a suitable retinoid or retinoid related molecule, are provided.

IPC 1-7 (main, further and additional classification)

A01N 37/10; A61K 31/19

IPC 8 full level (invention and additional information)

A61P 25/04 (2006.01); A61K 31/192 (2006.01); A61K 31/195 (2006.01); A61K 31/203 (2006.01); A61K 31/216 (2006.01); A61K 31/255 (2006.01); A61K 31/295 (2006.01); A61K 31/343 (2006.01); A61K 31/357 (2006.01); A61K 31/381 (2006.01); A61K 31/382 (2006.01); A61K 31/385 (2006.01); A61P 1/16 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 13/08 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 307/79 (2006.01); C07D 317/30 (2006.01); C07D 319/06 (2006.01); C07D 333/40 (2006.01); C07D 333/54 (2006.01); C07D 339/06 (2006.01); C07D 339/08 (2006.01)

CPC (invention and additional information)

A61K 31/203 (2013.01)

Citation (search report)

  • [X] WO 9321146 A1
  • [X] EP 0749752 A1
  • [X] US 5324840 A
  • [X] EP 0747347 A1
  • [X] US 5455265 A
  • [X] EP 0694301 A1
  • [X] NAKAJIMA, MOTOWO ET AL: "Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells" CANCER RES. ( 1989 ), 49(7), 1698-706, XP008008736
  • [X] GOTTARDIS, MARCO M. ET AL: "Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand" CANCER RESEARCH ( 1996 ), 56(24), 5566-5570, XP001108852
  • [X] DAWSON ET AL: "Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, no. 17, 1995, pages 3368-3383, XP002148373 ISSN: 0022-2623
  • [X] LOPEZ-BOADO, YOLANDA S. ET AL: "Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RAR.alpha.-dependent signaling pathway" JOURNAL OF BIOLOGICAL CHEMISTRY ( 1996 ), 271(50), 32105-32111, XP001115034
  • [X] BOEHM M F ET AL: "SYNTHESIS AND STRUCTURE - ACTIVITY RELATIONSHIPS OF NOVEL RETINOID X RECEPTOR-SELECTIVE RETINOIDS" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 37, no. 18, 2 September 1994 (1994-09-02), pages 2930-2941, XP000615432 ISSN: 0022-2623
  • [X] BOEHM M F ET AL: "DESIGN AND SYNTHESIS OF POTENT RETINOID X RECEPTOR SELECTIVE LIGANDS THAT INDUCE APOPTOSIS IN LEUKEMIA CELLS" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, no. 16, 4 August 1995 (1995-08-04), pages 3146-3155, XP000615461 ISSN: 0022-2623
  • See also references of WO 9846076A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9846076 A1 19981022; AU 6895198 A 19981111; BR 9808866 A 20000801; EP 0973390 A1 20000126; EP 0973390 A4 20030319; JP 2001522350 A 20011113

INPADOC legal status

2006-11-17 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Country Code: HK

- Ref Legal Event Code: WD

- Ref Document Number: 1025717

- Country of Ref Document: HK

2003-11-19 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030424

2003-03-19 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030130

2002-12-11 [RIC1] CLASSIFICATION (CORRECTION)

- Free Format Text: 7A 01N 37/10 A, 7A 61K 31/19 B, 7A 61K 31/335 B, 7A 61K 31/385 B, 7A 61K 31/38 B, 7A 61K 31/34 B

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991111

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE