Global patent index - EP 0973553 A2

EP 0973553 A2 2000-01-26 - BLOOD-POOL CARRIER FOR LIPOPHILIC IMAGING AGENTS

Title (en)

BLOOD-POOL CARRIER FOR LIPOPHILIC IMAGING AGENTS

Title (de)

INTRAVASALRAUM.TRÄGER FÜR LIPOPHILE KONTRASTMITTEL

Title (fr)

VEHICULE DU POOL SANGUIN POUR AGENTS D'IMAGERIE LIPOPHILES

Publication

EP 0973553 A2 (EN)

Application

EP 98918097 A

Priority

  • US 9807239 W
  • US 4330597 P

Abstract (en)

[origin: WO9846275A2] A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.

IPC 1-7 (main, further and additional classification)

A61K 49/04; A61K 51/04; A61K 51/06; A61K 101/02; A61K 123/00

IPC 8 full level (invention and additional information)

A61K 49/04 (2006.01); A61K 51/04 (2006.01)

CPC (invention and additional information)

B82Y 5/00 (2013.01); A61K 49/0461 (2013.01); A61K 51/04 (2013.01); A61K 51/0406 (2013.01)

Citation (search report)

See references of WO 9846275A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9846275 A2 19981022; WO 9846275 A3 19990128; AU 7108798 A 19981111; CA 2286138 A1 19981022; EP 0973553 A2 20000126; JP 2001524957 A 20011204; KR 20010006195 A 20010126

INPADOC legal status

2003-02-19 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020817

2002-03-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020205

2000-05-10 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991111

2000-02-02 [RIC1] CLASSIFICATION (CORRECTION)

- Free Format Text: 7A 61K 49/04 A, 7A 61K 9/127 B

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE