EP 0973553 A2 20000126 - BLOOD-POOL CARRIER FOR LIPOPHILIC IMAGING AGENTS
Title (en)
BLOOD-POOL CARRIER FOR LIPOPHILIC IMAGING AGENTS
Title (de)
INTRAVASALRAUM.TRÄGER FÜR LIPOPHILE KONTRASTMITTEL
Title (fr)
VEHICULE DU POOL SANGUIN POUR AGENTS D'IMAGERIE LIPOPHILES
Publication
Application
Priority
- US 9807239 W 19980410
- US 4330597 P 19970411
Abstract (en)
[origin: WO9846275A2] A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
IPC 1-7
A61K 49/04; A61K 51/04; A61K 51/06; A61K 101/02; A61K 123/00
IPC 8 full level
A61K 49/04 (2006.01); A61K 51/04 (2006.01)
CPC (source: EP KR)
A61K 49/04 (2013.01 - KR); A61K 49/0461 (2013.01 - EP); A61K 51/04 (2013.01 - EP); A61K 51/0406 (2013.01 - EP); B82Y 5/00 (2013.01 - EP)
Citation (search report)
See references of WO 9846275A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9846275 A2 19981022; WO 9846275 A3 19990128; AU 7108798 A 19981111; CA 2286138 A1 19981022; EP 0973553 A2 20000126; JP 2001524957 A 20011204; KR 20010006195 A 20010126
DOCDB simple family (application)
US 9807239 W 19980410; AU 7108798 A 19980410; CA 2286138 A 19980410; EP 98918097 A 19980410; JP 54410898 A 19980410; KR 19997009275 A 19991008