Global patent index - EP 0973720 A1

EP 0973720 A1 2000-01-26 - 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES

Title (en)

2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES

Title (de)

2-SUBSTITUIERTE BENZOYL-CYCLOALKYL-1-CARBONSÄUREDERIVATE

Title (fr)

DERIVES D'ACIDES BENZOYLE-CYCLOALKYL-1-CARBOXYLIQUES-2-SUBSTITUES

Publication

EP 0973720 A1 (EN)

Application

EP 98910685 A

Priority

  • EP 9800883 W
  • GB 9705031 A

Abstract (en)

[origin: WO9840344A1] 2-(substituted benzoyl)-cycloalkyl-1-carboxylic acids of formula (I) wherein E is a C1-C4 alkylene chain in which a carbon atom is optionally substituted; each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4; R2 is hydrogen or -N(R7R8) in which each of R7 and R8 is, independently, hydrogen, C1-C6 alkyl, benzyl, phenyl, hydroxy, C1-C6 alkoxy, benzyloxy or one of R7 and R8 is hydrogen and the other is COR9; R3 is hydroxy, C1-C6 alkoxy, phenoxy, benzyloxy or a group -N(R12R13); and pharmaceutically acceptable salts thereof, have kynurenine-3-hydroxylase enzyme inhibitor activity.

IPC 1-7 (main, further and additional classification)

C07C 62/20; A61K 31/16; A61K 31/195; C07C 229/12; C07C 233/58

IPC 8 full level (invention and additional information)

C07D 263/42 (2006.01); A61K 31/165 (2006.01); A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61P 9/10 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 51/09 (2006.01); C07C 62/28 (2006.01); C07C 62/38 (2006.01); C07C 67/14 (2006.01); C07C 69/743 (2006.01); C07C 69/757 (2006.01); C07C 227/18 (2006.01); C07C 229/48 (2006.01); C07C 233/60 (2006.01); C07C 233/81 (2006.01); C07C 235/82 (2006.01); C07C 237/24 (2006.01); C07C 259/08 (2006.01); C07C 271/24 (2006.01); C07C 271/64 (2006.01); C07C 311/51 (2006.01); C07D 263/52 (2006.01)

CPC (invention and additional information)

C07C 233/81 (2013.01); C07C 62/38 (2013.01); C07C 69/757 (2013.01); C07C 229/48 (2013.01); C07C 233/60 (2013.01); C07C 235/82 (2013.01); C07C 271/24 (2013.01); C07C 271/64 (2013.01); C07C 311/51 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01)

Citation (search report)

See references of WO 9840344A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

EPO simple patent family

WO 9840344 A1 19980917; AU 6497998 A 19980929; CA 2283184 A1 19980917; CN 1252049 A 20000503; EP 0973720 A1 20000126; GB 9705031 D0 19970430; HU 0001023 A2 20000928; HU 0001023 A3 20010328; IL 131676 D0 20010319; JP 2001514634 A 20010911; KR 20000076096 A 20001226; NO 994386 A 19991102; NO 994386 D0 19990910; PL 335601 A1 20000508; TW 407146 B 20001001; ZA 9801972 B 19980909

INPADOC legal status

2001-05-09 [18W] WITHDRAWN

- Date of withdrawal: 20010223

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990920

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

2000-01-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free Format Text: SI PAYMENT 19990920