EP 0973720 A1 20000126 - 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES
Title (en)
2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES
Title (de)
2-SUBSTITUIERTE BENZOYL-CYCLOALKYL-1-CARBONSÄUREDERIVATE
Title (fr)
DERIVES D'ACIDES BENZOYLE-CYCLOALKYL-1-CARBOXYLIQUES-2-SUBSTITUES
Publication
Application
Priority
- EP 9800883 W 19980216
- GB 9705031 A 19970311
Abstract (en)
[origin: WO9840344A1] 2-(substituted benzoyl)-cycloalkyl-1-carboxylic acids of formula (I) wherein E is a C1-C4 alkylene chain in which a carbon atom is optionally substituted; each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4; R2 is hydrogen or -N(R7R8) in which each of R7 and R8 is, independently, hydrogen, C1-C6 alkyl, benzyl, phenyl, hydroxy, C1-C6 alkoxy, benzyloxy or one of R7 and R8 is hydrogen and the other is COR9; R3 is hydroxy, C1-C6 alkoxy, phenoxy, benzyloxy or a group -N(R12R13); and pharmaceutically acceptable salts thereof, have kynurenine-3-hydroxylase enzyme inhibitor activity.
IPC 1-7
C07C 62/20; C07C 229/12; C07C 233/58; A61K 31/195; A61K 31/16
IPC 8 full level
C07D 263/42 (2006.01); A61K 31/165 (2006.01); A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61P 9/10 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 51/09 (2006.01); C07C 62/28 (2006.01); C07C 62/38 (2006.01); C07C 67/14 (2006.01); C07C 69/743 (2006.01); C07C 69/757 (2006.01); C07C 227/18 (2006.01); C07C 229/48 (2006.01); C07C 233/60 (2006.01); C07C 233/81 (2006.01); C07C 235/82 (2006.01); C07C 237/24 (2006.01); C07C 259/08 (2006.01); C07C 271/24 (2006.01); C07C 271/64 (2006.01); C07C 311/51 (2006.01); C07D 263/52 (2006.01)
CPC (source: EP KR)
A61P 9/10 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 62/20 (2013.01 - KR); C07C 62/38 (2013.01 - EP); C07C 69/757 (2013.01 - EP); C07C 229/48 (2013.01 - EP); C07C 233/60 (2013.01 - EP); C07C 233/81 (2013.01 - EP); C07C 235/82 (2013.01 - EP); C07C 271/24 (2013.01 - EP); C07C 271/64 (2013.01 - EP); C07C 311/51 (2013.01 - EP); C07C 2601/02 (2017.04 - EP); C07C 2601/04 (2017.04 - EP); C07C 2601/08 (2017.04 - EP)
Citation (search report)
See references of WO 9840344A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9840344 A1 19980917; AU 6497998 A 19980929; CA 2283184 A1 19980917; CN 1252049 A 20000503; EA 199900809 A1 20000828; EP 0973720 A1 20000126; GB 9705031 D0 19970430; HU P0001023 A2 20000928; HU P0001023 A3 20010328; IL 131676 A0 20010319; JP 2001514634 A 20010911; KR 20000076096 A 20001226; NO 994386 D0 19990910; NO 994386 L 19991102; PL 335601 A1 20000508; TW 407146 B 20001001; ZA 981972 B 19980909
DOCDB simple family (application)
EP 9800883 W 19980216; AU 6497998 A 19980216; CA 2283184 A 19980216; CN 98804144 A 19980216; EA 199900809 A 19980216; EP 98910685 A 19980216; GB 9705031 A 19970311; HU P0001023 A 19980216; IL 13167698 A 19980216; JP 53912398 A 19980216; KR 19997008184 A 19990909; NO 994386 A 19990910; PL 33560198 A 19980216; TW 87102847 A 19980226; ZA 981972 A 19980309