Global Patent Index - EP 0973720 A1

EP 0973720 A1 2000-01-26 - 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES

Title (en)

2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES

Title (de)

2-SUBSTITUIERTE BENZOYL-CYCLOALKYL-1-CARBONSÄUREDERIVATE

Title (fr)

DERIVES D'ACIDES BENZOYLE-CYCLOALKYL-1-CARBOXYLIQUES-2-SUBSTITUES

Publication

EP 0973720 A1 (EN)

Application

EP 98910685 A

Priority

  • EP 9800883 W
  • GB 9705031 A

Abstract (en)

[origin: WO9840344A1] 2-(substituted benzoyl)-cycloalkyl-1-carboxylic acids of formula (I) wherein E is a C1-C4 alkylene chain in which a carbon atom is optionally substituted; each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4; R2 is hydrogen or -N(R7R8) in which each of R7 and R8 is, independently, hydrogen, C1-C6 alkyl, benzyl, phenyl, hydroxy, C1-C6 alkoxy, benzyloxy or one of R7 and R8 is hydrogen and the other is COR9; R3 is hydroxy, C1-C6 alkoxy, phenoxy, benzyloxy or a group -N(R12R13); and pharmaceutically acceptable salts thereof, have kynurenine-3-hydroxylase enzyme inhibitor activity.

IPC 1-7

C07C 62/20; C07C 229/12; C07C 233/58; A61K 31/195; A61K 31/16

IPC 8 full level

C07D 263/42 (2006.01); A61K 31/165 (2006.01); A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61P 9/10 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 51/09 (2006.01); C07C 62/28 (2006.01); C07C 62/38 (2006.01); C07C 67/14 (2006.01); C07C 69/743 (2006.01); C07C 69/757 (2006.01); C07C 227/18 (2006.01); C07C 229/48 (2006.01); C07C 233/60 (2006.01); C07C 233/81 (2006.01); C07C 235/82 (2006.01); C07C 237/24 (2006.01); C07C 259/08 (2006.01); C07C 271/24 (2006.01); C07C 271/64 (2006.01); C07C 311/51 (2006.01); C07D 263/52 (2006.01)

CPC (source: EP)

A61P 25/08 (2018.01); A61P 25/14 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); C07C 62/38 (2013.01); C07C 69/757 (2013.01); C07C 229/48 (2013.01); C07C 233/60 (2013.01); C07C 233/81 (2013.01); C07C 235/82 (2013.01); C07C 271/24 (2013.01); C07C 271/64 (2013.01); C07C 311/51 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family

WO 9840344 A1 19980917; AU 6497998 A 19980929; CA 2283184 A1 19980917; CN 1252049 A 20000503; EA 199900809 A1 20000828; EP 0973720 A1 20000126; GB 9705031 D0 19970430; HU 0001023 A2 20000928; HU 0001023 A3 20010328; IL 131676 D0 20010319; JP 2001514634 A 20010911; KR 20000076096 A 20001226; NO 994386 D0 19990910; NO 994386 L 19991102; PL 335601 A1 20000508; TW 407146 B 20001001; ZA 9801972 B 19980909