Global Patent Index - EP 0973742 A1

EP 0973742 A1 2000-01-26 - ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE

Title (en)

ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE

Title (de)

ENDOTHELIN-ZWISCHENPRODUKTE DURCH EINE ASYMMETRISCH KONJUGIERTE ADDITIONSREAKTION UNTER VERWENDUNG EINES CHIRALEN ADDITIVES

Title (fr)

INTERMEDIAIRES DE L'ENDOTHELINE OBTENUS PAR REACTION D'ADDITION D'UN CONJUGUE ASYMETRIQUE EFFECTUEE AU MOYEN D'UN ADDITIF CHIRAL

Publication

EP 0973742 A1 (EN)

Application

EP 98902416 A

Priority

  • GB 9705858 A
  • US 9800263 W
  • US 3546297 P

Abstract (en)

[origin: WO9830543A1] This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.

IPC 1-7 (main, further and additional classification)

C07D 213/30; A61K 31/44; C07B 37/02; C07D 213/48

IPC 8 full level (invention and additional information)

C07B 37/02 (2006.01); C07B 53/00 (2006.01); C07D 213/30 (2006.01); C07D 213/48 (2006.01); C07D 213/55 (2006.01); C07D 213/56 (2006.01); C07D 213/85 (2006.01); C07D 263/06 (2006.01); C07D 263/52 (2006.01)

CPC (invention and additional information)

C07D 213/30 (2013.01); C07B 53/00 (2013.01); C07D 213/48 (2013.01); C07D 213/55 (2013.01); C07D 213/85 (2013.01); C07D 263/52 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 9830543A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9830543 A1 19980716; AU 5908998 A 19980803; AU 728441 B2 20010111; BR 9806875 A 20000418; CA 2277161 A1 19980716; CN 1243509 A 20000202; EA 002056 B1 20011224; EA 199900661 A1 20000228; EP 0973742 A1 20000126; HR P980001 A2 19981031; JP 2000507969 A 20000627; KR 20000070085 A 20001125; NZ 336220 A 20001222; PL 334318 A1 20000214; SK 93499 A3 20000516; TW 432028 B 20010501; YU 30499 A 20020619

INPADOC legal status


2002-08-14 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020205

2001-09-05 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010723

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990816

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-01-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: RO PAYMENT 19990816;SI PAYMENT 19990816