Global Patent Index - EP 0973745 A1

EP 0973745 A1 2000-01-26 - METHOD FOR THE PRODUCTION OF 2,6-DICHLORO-5-FLUORONICOTINONITRILE AND THE CHEMICAL COMPOUND 3-CYANO-2-HYDROXY-5-FLUOROPYRIDE-6-ONE-MONOSODIUM SALT AND ITS TAUTOMERS

Title (en)

METHOD FOR THE PRODUCTION OF 2,6-DICHLORO-5-FLUORONICOTINONITRILE AND THE CHEMICAL COMPOUND 3-CYANO-2-HYDROXY-5-FLUOROPYRIDE-6-ONE-MONOSODIUM SALT AND ITS TAUTOMERS

Title (de)

VERFAHREN ZUR HERSTELLUNG VON 2,6-DICHLOR-5-FLUORNICOTINONITRIL UND DIE CHEMISCHE VERBINDUNG 3-CYANO-2-HYDROXY-5-FLUORPYRID-6-ON-MONONATRIUMSALZ SOWIE DESSEN TAUTOMERE

Title (fr)

PROCEDE DE PREPARATION DE 2,6-DICHLORO-5-FLUORONICOTINONITRILE ET COMPOSE CHIMIQUE 3-CYANO-2-HYDROXY-5-FLUOROPYRIDE-6-ONE-SEL MONOSODIQUE AINSI QUE SES TAUTOMERES

Publication

EP 0973745 A1 (DE)

Application

EP 98917018 A

Priority

  • DE 19713506 A
  • EP 9801617 W

Abstract (en)

[origin: DE19713506A1] The invention relates to 2,6-dichloro-5-fluoronicotinitrile which can be advantageously obtained by reacting 3-cyano-2-hydroxy-5-fluoropyride-6-one and/or its tautomers and/or its salts and/or their tautomers with phosphorus trichloride and chloric gas in a solvent with addition of a basic catalyst at temperatures between 30 and 300 DEG C, and then by hydrolysis. The 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt which can be used is a new chemical compound that is easy to obtain from 3-cyano-2-hydroxy-5-fluoropyride-6-one and/or its tautomers by reaction with alcoholate and precipitation with a moderately weak acid.

IPC 1-7 (main, further and additional classification)

C07D 213/85; A61K 31/44; C07B 39/00

IPC 8 full level (invention and additional information)

C07D 213/84 (2006.01); C07B 39/00 (2006.01); C07D 213/85 (2006.01)

CPC (invention and additional information)

C07B 39/00 (2013.01); C07D 213/85 (2013.01)

Citation (search report)

See references of WO 9843958A1

Designated contracting state (EPC)

AT BE CH DE ES FI FR GB IE IT LI NL PT

EPO simple patent family

DE 19713506 A1 19981008; AU 7038598 A 19981022; CA 2285365 A1 19981008; CN 1259123 A 20000705; EP 0973745 A1 20000126; HU 0003630 A2 20010328; IL 131973 D0 20010319; JP 2001516364 A 20010925; KR 20010005843 A 20010115; PL 335939 A1 20000522; TW 509662 B 20021111; US 6197964 B1 20010306; WO 9843958 A1 19981008

INPADOC legal status


2001-03-07 [18W] WITHDRAWN

- Date of withdrawal: 20010108

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991102

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE ES FI FR GB IE IT LI NL PT