Global Patent Index - EP 0973749 A1

EP 0973749 A1 20000126 - 4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS

Title (en)

4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS

Title (de)

4-AMINOALKOXY-1H-BENZIMIDAZOL DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN

Title (fr)

DERIVES DE 4-AMINOALCOXY-1H-BENZIMIDAZOLE, LEUR PREPARATION ET LEUR UTILISATION COMME AGONISTES DES AUTORECEPTEURS DE LA DOPAMINE (D 2?)

Publication

EP 0973749 A1 (EN)

Application

EP 98902513 A

Priority

  • US 9800613 W
  • US 80127697 A

Abstract (en)

[origin: WO9835945A1] This invention relates to D2 dopaminergic compounds of formula (I), wherein R<1> is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group having up to 6 carbons or benzyl optionally substituted by one to three substituents selected from halogen, amino, nitro, hydroxy, C1-C6 alkoxy; R<2> is hydrogen or C1-C6 alkyl. R3 is hydrogen, straight-chain or branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl, -(CH2)mAr, where Ar is phenyl, thienyl, furanyl, or pyridinyl, each optionally substituted by one to two substituents selected from halogen, C1-C6 alkoxy, trifluoromethyl or C1-C6 alkyl; or NR<2>R<3> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; Y = halogen, lower alkyl, amino, and lower alkoxy; n = 1-5; or a pharmaceutically acceptable salt thereof. These D2 dopaminergic compounds are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, and drug or alcohol addiction.

IPC 1-7

C07D 235/06; A61K 31/415; C07D 235/08; C07D 235/10; C07D 409/12; C07D 401/12; A61K 31/47

IPC 8 full level

A61K 31/4184 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 235/06 (2006.01); C07D 235/08 (2006.01); C07D 235/10 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)

CPC (source: EP)

A61P 25/00 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/30 (2018.01); A61P 43/00 (2018.01); C07D 235/06 (2013.01); C07D 235/08 (2013.01); C07D 235/10 (2013.01); C07D 401/12 (2013.01); C07D 409/12 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9835945 A1 19980820; AR 011136 A1 20000802; AU 5915398 A 19980908; AU 746717 B2 20020502; BR 9807701 A 20000502; CA 2278700 A1 19980820; CN 1252793 A 20000510; EP 0973749 A1 20000126; HU 0001302 A2 20010528; HU 0001302 A3 20010730; IL 131158 D0 20010128; JP 2001509814 A 20010724; KR 20000071129 A 20001125; NZ 336969 A 20010330; TW 513415 B 20021211; ZA 9801309 B 19990817

DOCDB simple family (application)

US 9800613 W 19980113; AR P980100617 A 19980211; AU 5915398 A 19980113; BR 9807701 A 19980113; CA 2278700 A 19980113; CN 98804249 A 19980113; EP 98902513 A 19980113; HU 0001302 A 19980113; IL 13115898 A 19980113; JP 53572798 A 19980113; KR 19997007418 A 19990816; NZ 33696998 A 19980113; TW 87101275 A 19980203; ZA 9801309 A 19980217