Global Patent Index - EP 0973749 A1

EP 0973749 A1 20000126 - 4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS

Title (en)

4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS

Title (de)

4-AMINOALKOXY-1H-BENZIMIDAZOL DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN

Title (fr)

DERIVES DE 4-AMINOALCOXY-1H-BENZIMIDAZOLE, LEUR PREPARATION ET LEUR UTILISATION COMME AGONISTES DES AUTORECEPTEURS DE LA DOPAMINE (D 2?)

Publication

EP 0973749 A1 20000126 (EN)

Application

EP 98902513 A 19980113

Priority

  • US 9800613 W 19980113
  • US 80127697 A 19970218

Abstract (en)

[origin: WO9835945A1] This invention relates to D2 dopaminergic compounds of formula (I), wherein R<1> is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group having up to 6 carbons or benzyl optionally substituted by one to three substituents selected from halogen, amino, nitro, hydroxy, C1-C6 alkoxy; R<2> is hydrogen or C1-C6 alkyl. R3 is hydrogen, straight-chain or branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl, -(CH2)mAr, where Ar is phenyl, thienyl, furanyl, or pyridinyl, each optionally substituted by one to two substituents selected from halogen, C1-C6 alkoxy, trifluoromethyl or C1-C6 alkyl; or NR<2>R<3> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; Y = halogen, lower alkyl, amino, and lower alkoxy; n = 1-5; or a pharmaceutically acceptable salt thereof. These D2 dopaminergic compounds are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, and drug or alcohol addiction.

IPC 1-7

C07D 235/06; A61K 31/415; A61K 31/47; C07D 235/08; C07D 235/10; C07D 401/12; C07D 409/12

IPC 8 full level

A61K 31/4184 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 235/06 (2006.01); C07D 235/08 (2006.01); C07D 235/10 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)

CPC (source: EP)

A61P 25/00 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/30 (2018.01); A61P 43/00 (2018.01); C07D 235/06 (2013.01); C07D 235/08 (2013.01); C07D 235/10 (2013.01); C07D 401/12 (2013.01); C07D 409/12 (2013.01)

Citation (search report)

See references of WO 9835945A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9835945 A1 19980820; AR 011136 A1 20000802; AU 5915398 A 19980908; AU 746717 B2 20020502; BR 9807701 A 20000502; CA 2278700 A1 19980820; CN 1252793 A 20000510; EP 0973749 A1 20000126; HU 0001302 A2 20010528; HU 0001302 A3 20010730; IL 131158 D0 20010128; JP 2001509814 A 20010724; KR 20000071129 A 20001125; NZ 336969 A 20010330; TW 513415 B 20021211; ZA 981309 B 19990817

DOCDB simple family (application)

US 9800613 W 19980113; AR P980100617 A 19980211; AU 5915398 A 19980113; BR 9807701 A 19980113; CA 2278700 A 19980113; CN 98804249 A 19980113; EP 98902513 A 19980113; HU 0001302 A 19980113; IL 13115898 A 19980113; JP 53572798 A 19980113; KR 19997007418 A 19990816; NZ 33696998 A 19980113; TW 87101275 A 19980203; ZA 981309 A 19980217