EP 0973749 A1 20000126 - 4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (en)
4-AMINOALKOXY-1H-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (de)
4-AMINOALKOXY-1H-BENZIMIDAZOL DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN
Title (fr)
DERIVES DE 4-AMINOALCOXY-1H-BENZIMIDAZOLE, LEUR PREPARATION ET LEUR UTILISATION COMME AGONISTES DES AUTORECEPTEURS DE LA DOPAMINE (D 2?)
Publication
Application
Priority
- US 9800613 W 19980113
- US 80127697 A 19970218
Abstract (en)
[origin: WO9835945A1] This invention relates to D2 dopaminergic compounds of formula (I), wherein R<1> is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group having up to 6 carbons or benzyl optionally substituted by one to three substituents selected from halogen, amino, nitro, hydroxy, C1-C6 alkoxy; R<2> is hydrogen or C1-C6 alkyl. R3 is hydrogen, straight-chain or branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl, -(CH2)mAr, where Ar is phenyl, thienyl, furanyl, or pyridinyl, each optionally substituted by one to two substituents selected from halogen, C1-C6 alkoxy, trifluoromethyl or C1-C6 alkyl; or NR<2>R<3> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; Y = halogen, lower alkyl, amino, and lower alkoxy; n = 1-5; or a pharmaceutically acceptable salt thereof. These D2 dopaminergic compounds are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, and drug or alcohol addiction.
IPC 1-7
C07D 235/06; A61K 31/415; C07D 235/08; C07D 235/10; C07D 409/12; C07D 401/12; A61K 31/47
IPC 8 full level
A61K 31/4184 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 235/06 (2006.01); C07D 235/08 (2006.01); C07D 235/10 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR)
A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 235/06 (2013.01 - EP KR); C07D 235/08 (2013.01 - EP); C07D 235/10 (2013.01 - EP); C07D 401/12 (2013.01 - EP); C07D 409/12 (2013.01 - EP)
Citation (search report)
See references of WO 9835945A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9835945 A1 19980820; AR 011136 A1 20000802; AU 5915398 A 19980908; AU 746717 B2 20020502; BR 9807701 A 20000502; CA 2278700 A1 19980820; CN 1252793 A 20000510; EP 0973749 A1 20000126; HU 0001302 A2 20010528; HU 0001302 A3 20010730; IL 131158 A0 20010128; JP 2001509814 A 20010724; KR 20000071129 A 20001125; NZ 336969 A 20010330; TW 513415 B 20021211; ZA 981309 B 19990817
DOCDB simple family (application)
US 9800613 W 19980113; AR P980100617 A 19980211; AU 5915398 A 19980113; BR 9807701 A 19980113; CA 2278700 A 19980113; CN 98804249 A 19980113; EP 98902513 A 19980113; HU 0001302 A 19980113; IL 13115898 A 19980113; JP 53572798 A 19980113; KR 19997007418 A 19990816; NZ 33696998 A 19980113; TW 87101275 A 19980203; ZA 981309 A 19980217