EP 0973773 A1 20000126 - PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION
Title (en)
PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION
Title (de)
PYRIMIDO-ISOCHINOLINVERBINDUNGEN MIT NERVENSCHÜTZENDER WIRKUNG
Title (fr)
COMPOSES DE PYRIMIDO-ISOQUINOLINE A ACTION ANTICONVULSIVE
Publication
Application
Priority
- EP 9802139 W 19980403
- GB 9707251 A 19970410
Abstract (en)
[origin: WO9845293A1] A method of treatment and/or prophylaxis of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, MS and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction and amyotrophic lateral sclerosis (ALS) comprises administering to the sufferer in need thereof an effective or prophylatic amount of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof; in which R<1> is hydrogen or up to three substituents independently selected from halogen, C1-6alkyl, C1-6alkoxy, C1-6alkylcarbonyl and hydroxy C1-6alkyl, or two R<1> groups form a methylenedioxy; R<2> is hydrogen or C1-6alkyl, and R is R<3> or R<3>CO where R<3> is C3-7cycloalkyl, phenyl or phenyl C1-6alkyl in which the cyclic moieties are optionally substituted by up to three substituents independently selected from halogen, C1-6alkyl, C1-6alkoxy, C1-6alkylcarbonyl, hydroxy C1-6alkyl and phenylcarbonyloxy C1-6alkyl.
IPC 1-7
IPC 8 full level
A61K 31/519 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/06 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 43/00 (2017.12); C07D 471/04 (2013.01)
Citation (search report)
See references of WO 9845293A1
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9845293 A1 19981015; CA 2286452 A1 19981015; EP 0973773 A1 20000126; GB 9707251 D0 19970528; JP 2001519798 A 20011023
DOCDB simple family (application)
EP 9802139 W 19980403; CA 2286452 A 19980403; EP 98919259 A 19980403; GB 9707251 A 19970410; JP 54240998 A 19980403