Global patent index - EP 0973773 A1

EP 0973773 A1 2000-01-26 - PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION

Title (en)

PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION

Title (de)

PYRIMIDO-ISOCHINOLINVERBINDUNGEN MIT NERVENSCHÜTZENDER WIRKUNG

Title (fr)

COMPOSES DE PYRIMIDO-ISOQUINOLINE A ACTION ANTICONVULSIVE

Publication

EP 0973773 A1 (EN)

Application

EP 98919259 A

Priority

  • EP 9802139 W
  • GB 9707251 A

Abstract (en)

[origin: WO9845293A1] A method of treatment and/or prophylaxis of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, MS and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction and amyotrophic lateral sclerosis (ALS) comprises administering to the sufferer in need thereof an effective or prophylatic amount of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof; in which R<1> is hydrogen or up to three substituents independently selected from halogen, C1-6alkyl, C1-6alkoxy, C1-6alkylcarbonyl and hydroxy C1-6alkyl, or two R<1> groups form a methylenedioxy; R<2> is hydrogen or C1-6alkyl, and R is R<3> or R<3>CO where R<3> is C3-7cycloalkyl, phenyl or phenyl C1-6alkyl in which the cyclic moieties are optionally substituted by up to three substituents independently selected from halogen, C1-6alkyl, C1-6alkoxy, C1-6alkylcarbonyl, hydroxy C1-6alkyl and phenylcarbonyloxy C1-6alkyl.

IPC 1-7 (main, further and additional classification)

C07D 471/04; A61K 31/505

IPC 8 full level (invention and additional information)

A61P 25/04 (2006.01); A61K 31/519 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01)

CPC (invention and additional information)

C07D 471/04 (2013.01)

Citation (search report)

See references of WO 9845293A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9845293 A1 19981015; CA 2286452 A1 19981015; EP 0973773 A1 20000126; GB 9707251 D0 19970528; JP 2001519798 A 20011023

INPADOC legal status

2002-05-22 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011101

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991007

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE ES FR GB IT LI NL