Global Patent Index - EP 0973775 A1

EP 0973775 A1 20000126 - PYROLOPYRROLONE DERIVATIVES

Title (en)

PYROLOPYRROLONE DERIVATIVES

Title (de)

MENSCHLICHE NEURONALE ZELL LINIE

Title (fr)

DERIVES DE PYROLOPYRROLONE

Publication

EP 0973775 A1 20000126 (EN)

Application

EP 98914960 A 19980402

Priority

  • GB 9800982 W 19980402
  • GB 9706668 A 19970402
  • GB 9719151 A 19970909
  • GB 9719189 A 19970909

Abstract (en)

[origin: WO9843975A1] The present invention relates to therapeutically active bicyclic compounds, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in treatment and prophylaxis, particularly of viral infections, more particularly of infections caused by viruses which encode for a serine protease enzyme, especially viruses of the herpes family. Thus, according to one aspect of this invention, we provide a compound of general formula (I) wherein R represents H, substituted or unsubstituted C1-3 alkyl; R1 represents optionally substituted heteroaryl or fused heteroaryl with one to four heteroatoms, R5CO, R5NHCO, R5CS or R5NHCS wherein R5 may be substituted or unsubstituted and represents H, C1-6 alkyl, C1-6 alkenyl, C3-7 cylcoalkyl or fused cycloalkyl, heteroaryl or fused heteroaryl containing one to four heteroatoms, aryl or fused aryl, or arylC1-3alkyl; R2 represents R6-X- or R3CO, wherein R3 may be substituted or unsubstituted and represents (A), (B), (C), (D), (E), (F), (G), or (H), optionally including one or more further heteroatoms; R4 represents R6-X-; R6 is optionally substituted heterocyclic or fused heterocyclic with 1-4 heteroatoms, heteroaryl or fused heteroaryl with 1-4 heteroatoms, C3-10cycloalkyl or fused cycloalkyl, aryl or fused aryl; and X represents a linker group chosen from C=O, NHC=O, C(=O)C=O, CH=CHCO, CH2CO, CH2 or SO2; and salts and solvates thereof.

IPC 1-7

C07D 487/04; A61K 31/40; C07D 207/14

IPC 8 full level

A61K 31/407 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61P 31/22 (2006.01); A61P 43/00 (2006.01); C07D 207/14 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)

CPC (source: EP)

A61P 31/22 (2018.01); A61P 43/00 (2018.01); C07D 207/14 (2013.01); C07D 487/04 (2013.01)

Citation (search report)

See references of WO 9843975A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9843975 A1 19981008; AU 6926198 A 19981022; CA 2286367 A1 19981008; EP 0973775 A1 20000126; JP 2000513013 A 20001003

DOCDB simple family (application)

GB 9800982 W 19980402; AU 6926198 A 19980402; CA 2286367 A 19980402; EP 98914960 A 19980402; JP 54132098 A 19980402