Global patent index - EP 0973775 A1

EP 0973775 A1 2000-01-26 - PYROLOPYRROLONE DERIVATIVES

Title (en)

PYROLOPYRROLONE DERIVATIVES

Title (de)

MENSCHLICHE NEURONALE ZELL LINIE

Title (fr)

DERIVES DE PYROLOPYRROLONE

Publication

EP 0973775 A1 (EN)

Application

EP 98914960 A

Priority

  • GB 9800982 W
  • GB 9706668 A
  • GB 9719151 A
  • GB 9719189 A

Abstract (en)

[origin: WO9843975A1] The present invention relates to therapeutically active bicyclic compounds, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in treatment and prophylaxis, particularly of viral infections, more particularly of infections caused by viruses which encode for a serine protease enzyme, especially viruses of the herpes family. Thus, according to one aspect of this invention, we provide a compound of general formula (I) wherein R represents H, substituted or unsubstituted C1-3 alkyl; R1 represents optionally substituted heteroaryl or fused heteroaryl with one to four heteroatoms, R5CO, R5NHCO, R5CS or R5NHCS wherein R5 may be substituted or unsubstituted and represents H, C1-6 alkyl, C1-6 alkenyl, C3-7 cylcoalkyl or fused cycloalkyl, heteroaryl or fused heteroaryl containing one to four heteroatoms, aryl or fused aryl, or arylC1-3alkyl; R2 represents R6-X- or R3CO, wherein R3 may be substituted or unsubstituted and represents (A), (B), (C), (D), (E), (F), (G), or (H), optionally including one or more further heteroatoms; R4 represents R6-X-; R6 is optionally substituted heterocyclic or fused heterocyclic with 1-4 heteroatoms, heteroaryl or fused heteroaryl with 1-4 heteroatoms, C3-10cycloalkyl or fused cycloalkyl, aryl or fused aryl; and X represents a linker group chosen from C=O, NHC=O, C(=O)C=O, CH=CHCO, CH2CO, CH2 or SO2; and salts and solvates thereof.

IPC 1-7 (main, further and additional classification)

C07D 487/04; A61K 31/40; C07D 207/14

IPC 8 full level (invention and additional information)

A61K 31/407 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61P 31/22 (2006.01); A61P 43/00 (2006.01); C07D 207/14 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)

CPC (invention and additional information)

C07D 487/04 (2013.01); C07D 207/14 (2013.01)

Citation (search report)

See references of WO 9843975A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9843975 A1 19981008; AU 6926198 A 19981022; CA 2286367 A1 19981008; EP 0973775 A1 20000126; JP 2000513013 A 20001003

INPADOC legal status

2002-07-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020108

2001-10-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010828

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990930

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-01-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free Format Text: AL PAYMENT 19990930;LT PAYMENT 19990930;LV PAYMENT 19990930;MK PAYMENT 19990930;RO PAYMENT 19990930;SI PAYMENT 19990930