Global patent index - EP 0973904 A1

EP 0973904 A1 2000-01-26 - COMPOSITIONS AND USE OF M-CSF-alpha

Title (en)

COMPOSITIONS AND USE OF M-CSF-alpha

Title (de)

Zusammensetzungen und Verwendungen von M-CSF-alpha

Title (fr)

COMPOSITIONS ET UTILISATIONS DE M-CSF-alpha

Publication

EP 0973904 A1 (EN)

Application

EP 98910322 A

Priority

  • US 9804802 W
  • US 3858397 P

Abstract (en)

[origin: WO9839449A1] The invention is a method and composition for reducing a population of diseased cells by administration of a gene delivery vehicle capable of expressing an M-CSF alpha mutant having a decreased capacity to be proteolytically processed and released from a cell membrane. The invention is also a combination of therapeutic agents including gene delivery vehicles expressing M-CSF alpha or an M-CSF alpha mutant in combination, for example, either with a soluble M-CSF, an M-CSF alpha convertase inhibitor, or a gene delivery vehicle expressing prodrug activator such as thymidine kinase followed by administration of the prodrug.

IPC 1-7 (main, further and additional classification)

C12N 15/27; A61K 38/19; A61K 48/00; C07K 14/53

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/53 (2006.01); C12N 5/10 (2006.01); C12N 15/27 (2006.01)

CPC (invention and additional information)

C07K 14/53 (2013.01); A61K 38/193 (2013.01); A61K 48/00 (2013.01); C12N 2799/022 (2013.01)

Combination set (CPC)

A61K 38/193 + A61K 2300/00

Citation (search report)

See references of WO 9839449A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9839449 A1 19980911; AU 6458898 A 19980922; EP 0973904 A1 20000126; JP 2001517079 A 20011002

INPADOC legal status

2002-04-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011002

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990923

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE