EP 0973933 A1 20000126 - IMMUNOLOGICAL TOLERANCE TO HIV EPITOPES
Title (en)
IMMUNOLOGICAL TOLERANCE TO HIV EPITOPES
Title (de)
IMMUNTOLERANZ VON HIV EPITOPEN.
Title (fr)
TOLERANCE IMMUNOLOGIQUE AUX EPITOPES DU HIV
Publication
Application
Priority
- US 9802766 W 19980213
- US 4058197 P 19970213
Abstract (en)
[origin: WO9836087A1] Fusion immunoglobulin (fIg) proteins comprising one or more heterologous epitopes associated with a disease in which immune responsiveness is deleterious are useful to induce tolerance to these epitopes. HIV-1 gp120 epitopes linked in frame with an Ig heavy (H) chain are useful constructs for the induction of epitope-specific tolerance to HIV. Treatment of a subject with such a construct, or with lymphoid or hematopoietic cells expressing or secreting such fIg molecules induces specific immunological tolerance to those epitopes. Such tolerance, by preventing production of antibodies to selected gp120 epitopes, can prevent or inhibit "bystander" apoptosis of uninfected host T cells which have bound the HIV gp120 protein to their surface CD4 molecules and are subsequently cross-linked by undesired anti-gp120 antibodies, thereby priming them for apoptisis in the presence of antigens which activate those T cells. gp120 epitopes corresponding to non-neutralizing B cell epitopes or certain T helper cell epitopes are preferred for producing the fIg molecules. In addition to fIg H chains and complete Ig molecules, DNA encoding such H chain and cells transformed with such DNA are provided.
IPC 1-7
C12P 21/04; C12P 21/08; C07K 16/00; C07H 21/04; C12Q 1/70; G01N 33/53; A61K 39/00; A61K 39/21; A61K 39/395
IPC 8 full level
C07K 14/16 (2006.01); C07K 16/00 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/005 (2013.01); C07K 16/00 (2013.01); G01N 33/6878 (2013.01); A61K 38/00 (2013.01); C07K 2317/73 (2013.01); C07K 2319/00 (2013.01); C12N 2740/16122 (2013.01); G01N 2333/162 (2013.01)
Citation (search report)
See references of WO 9836087A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9836087 A1 19980820; CA 2279492 A1 19980820; EP 0973933 A1 20000126
DOCDB simple family (application)
US 9802766 W 19980213; CA 2279492 A 19980213; EP 98908538 A 19980213