Global Patent Index - EP 0973933 A1

EP 0973933 A1 2000-01-26 - IMMUNOLOGICAL TOLERANCE TO HIV EPITOPES

Title (en)

IMMUNOLOGICAL TOLERANCE TO HIV EPITOPES

Title (de)

IMMUNTOLERANZ VON HIV EPITOPEN.

Title (fr)

TOLERANCE IMMUNOLOGIQUE AUX EPITOPES DU HIV

Publication

EP 0973933 A1 (EN)

Application

EP 98908538 A

Priority

  • US 9802766 W
  • US 4058197 P

Abstract (en)

[origin: WO9836087A1] Fusion immunoglobulin (fIg) proteins comprising one or more heterologous epitopes associated with a disease in which immune responsiveness is deleterious are useful to induce tolerance to these epitopes. HIV-1 gp120 epitopes linked in frame with an Ig heavy (H) chain are useful constructs for the induction of epitope-specific tolerance to HIV. Treatment of a subject with such a construct, or with lymphoid or hematopoietic cells expressing or secreting such fIg molecules induces specific immunological tolerance to those epitopes. Such tolerance, by preventing production of antibodies to selected gp120 epitopes, can prevent or inhibit "bystander" apoptosis of uninfected host T cells which have bound the HIV gp120 protein to their surface CD4 molecules and are subsequently cross-linked by undesired anti-gp120 antibodies, thereby priming them for apoptisis in the presence of antigens which activate those T cells. gp120 epitopes corresponding to non-neutralizing B cell epitopes or certain T helper cell epitopes are preferred for producing the fIg molecules. In addition to fIg H chains and complete Ig molecules, DNA encoding such H chain and cells transformed with such DNA are provided.

IPC 1-7 (main, further and additional classification)

C12P 21/04; A61K 39/00; A61K 39/21; A61K 39/395; C07H 21/04; C07K 16/00; C12P 21/08; C12Q 1/70; G01N 33/53

IPC 8 full level (invention and additional information)

C07K 14/16 (2006.01); C07K 16/00 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/005 (2013.01); C07K 16/00 (2013.01); G01N 33/6878 (2013.01); A61K 38/00 (2013.01); C07K 2317/73 (2013.01); C07K 2319/00 (2013.01); C12N 2740/16122 (2013.01); G01N 2333/162 (2013.01)

Citation (search report)

See references of WO 9836087A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9836087 A1 19980820; CA 2279492 A1 19980820; EP 0973933 A1 20000126

INPADOC legal status


2003-03-12 [18W] WITHDRAWN

- Effective date: 20030114

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990913

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE