EP 0973935 A2 20000126 - TARGET GENES FOR ALLELE-SPECIFIC DRUGS
Title (en)
TARGET GENES FOR ALLELE-SPECIFIC DRUGS
Title (de)
ALLELE SPEZIFISCHE ZIELGENE
Title (fr)
GENES CIBLES POUR MEDICAMENTS SPECIFIQUES D'ALLELES
Publication
Application
Priority
- US 9805419 W 19980319
- US 4105797 P 19970320
Abstract (en)
[origin: WO9841648A2] This disclosure concerns genetic targets which have been found to be useful for allele specific anti-tumor therapy. The strategy for such therapy involves the steps of: (1) identification of alternative alleles of genes coding for proteins essential for cell viability or cell growth and the loss of one of these alleles in cancer cells due to loss of heterozygosity (LOH) and (2) the development of inhibitors with high specificity for the single remaining alternative allele of the essential gene retained by the tumor cell after LOH. Particular categories of appropriate target genes are described, along with specific exemplary genes within those categories and methods of using such target genes.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C12N 9/00 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C12N 9/00 (2013.01); G01N 33/5011 (2013.01); G01N 33/574 (2013.01)
Citation (search report)
See references of WO 9841648A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9841648 A2 19980924; WO 9841648 A3 19990429; AU 6764398 A 19981012; CA 2283636 A1 19980924; EP 0973935 A2 20000126
DOCDB simple family (application)
US 9805419 W 19980319; AU 6764398 A 19980319; CA 2283636 A 19980319; EP 98912974 A 19980319