Global Patent Index - EP 0973935 A2

EP 0973935 A2 2000-01-26 - TARGET GENES FOR ALLELE-SPECIFIC DRUGS

Title (en)

TARGET GENES FOR ALLELE-SPECIFIC DRUGS

Title (de)

ALLELE SPEZIFISCHE ZIELGENE

Title (fr)

GENES CIBLES POUR MEDICAMENTS SPECIFIQUES D'ALLELES

Publication

EP 0973935 A2 (EN)

Application

EP 98912974 A

Priority

  • US 9805419 W
  • US 4105797 P

Abstract (en)

[origin: WO9841648A2] This disclosure concerns genetic targets which have been found to be useful for allele specific anti-tumor therapy. The strategy for such therapy involves the steps of: (1) identification of alternative alleles of genes coding for proteins essential for cell viability or cell growth and the loss of one of these alleles in cancer cells due to loss of heterozygosity (LOH) and (2) the development of inhibitors with high specificity for the single remaining alternative allele of the essential gene retained by the tumor cell after LOH. Particular categories of appropriate target genes are described, along with specific exemplary genes within those categories and methods of using such target genes.

IPC 1-7 (main, further and additional classification)

C12Q 1/00; A61K 35/00; C07K 14/00; C12N 15/00

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C12N 9/00 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

C12N 9/00 (2013.01); C07K 14/47 (2013.01); G01N 33/5011 (2013.01); G01N 33/574 (2013.01)

Citation (search report)

See references of WO 9841648A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9841648 A2 19980924; WO 9841648 A3 19990429; AU 6764398 A 19981012; CA 2283636 A1 19980924; EP 0973935 A2 20000126

INPADOC legal status


2005-04-20 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041001

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990922

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE