Global Patent Index - EP 0973939 A1

EP 0973939 A1 2000-01-26 - EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION

Title (en)

EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION

Title (de)

AUFZEICHNUNG DER EXPRESSION ZUR IDENTIFIZIERUNG DER GENFUNKTION

Title (fr)

CONTROLE D'EXPRESSION GENIQUE PERMETTANT D'IDENTIFIER UNE FONCTION DE GENE

Publication

EP 0973939 A1 (EN)

Application

EP 98903639 A

Priority

  • US 9801206 W
  • US 3532797 P
  • US 4962797 P

Abstract (en)

[origin: WO9830722A1] This invention provides methods, compositions and apparatus for mapping the regulatory relationship among genes by massive parallel monitoring gene expression. In some embodiments, mutations in the up-stream regulatory genes are detected by monitoring the change in down-stream gene expression. Similarly, the function of a specific mutation in an up-stream gene is determined by monitoring the down-stream gene expression. In addition, regulatory function of a target gene can be determined by monitoring the expression of a large number of down-stream genes. The invention also provides specific embodiments for detecting p53 functional homozygous and heterozygous mutations and for determining the function of p53 mutations.

IPC 1-7 (main, further and additional classification)

C12Q 1/68

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12M 1/00 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6837 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9830722 A1 19980716; AU 6035698 A 19980803; EP 0973939 A1 20000126; EP 0973939 A4 20020710; JP 2001508303 A 20010626

INPADOC legal status


2008-09-03 [18R] REFUSED

- Effective date: 20080327

2003-03-05 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030120

2002-07-10 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020528

2002-07-10 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-01-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990730

2000-01-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE