EP 0973939 A1 20000126 - EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION
Title (en)
EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION
Title (de)
AUFZEICHNUNG DER EXPRESSION ZUR IDENTIFIZIERUNG DER GENFUNKTION
Title (fr)
CONTROLE D'EXPRESSION GENIQUE PERMETTANT D'IDENTIFIER UNE FONCTION DE GENE
Publication
Application
Priority
- US 9801206 W 19980112
- US 3532797 P 19970113
- US 4962797 P 19970613
Abstract (en)
[origin: WO9830722A1] This invention provides methods, compositions and apparatus for mapping the regulatory relationship among genes by massive parallel monitoring gene expression. In some embodiments, mutations in the up-stream regulatory genes are detected by monitoring the change in down-stream gene expression. Similarly, the function of a specific mutation in an up-stream gene is determined by monitoring the down-stream gene expression. In addition, regulatory function of a target gene can be determined by monitoring the expression of a large number of down-stream genes. The invention also provides specific embodiments for detecting p53 functional homozygous and heterozygous mutations and for determining the function of p53 mutations.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12M 1/00 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C12Q 1/68 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6837 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9830722 A1 19980716; AU 6035698 A 19980803; EP 0973939 A1 20000126; EP 0973939 A4 20020710; JP 2001508303 A 20010626
DOCDB simple family (application)
US 9801206 W 19980112; AU 6035698 A 19980112; EP 98903639 A 19980112; JP 53129498 A 19980112