Global Patent Index - EP 0973939 A1

EP 0973939 A1 2000-01-26 - EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION

Title (en)

EXPRESSION MONITORING FOR GENE FUNCTION IDENTIFICATION

Title (de)

AUFZEICHNUNG DER EXPRESSION ZUR IDENTIFIZIERUNG DER GENFUNKTION

Title (fr)

CONTROLE D'EXPRESSION GENIQUE PERMETTANT D'IDENTIFIER UNE FONCTION DE GENE

Publication

EP 0973939 A1 (EN)

Application

EP 98903639 A

Priority

  • US 9801206 W
  • US 3532797 P
  • US 4962797 P

Abstract (en)

[origin: WO9830722A1] This invention provides methods, compositions and apparatus for mapping the regulatory relationship among genes by massive parallel monitoring gene expression. In some embodiments, mutations in the up-stream regulatory genes are detected by monitoring the change in down-stream gene expression. Similarly, the function of a specific mutation in an up-stream gene is determined by monitoring the down-stream gene expression. In addition, regulatory function of a target gene can be determined by monitoring the expression of a large number of down-stream genes. The invention also provides specific embodiments for detecting p53 functional homozygous and heterozygous mutations and for determining the function of p53 mutations.

IPC 1-7

C12Q 1/68

IPC 8 full level

C12N 15/09 (2006.01); C12M 1/00 (2006.01); C12Q 1/68 (2006.01)

CPC

C12Q 1/6837 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/136 (2013.01)

DCS

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9830722 A1 19980716; AU 6035698 A 19980803; EP 0973939 A1 20000126; EP 0973939 A4 20020710; JP 2001508303 A 20010626