EP 0973946 A1 20000126 - BIOLOGICAL ASSAY FOR TESTING THE CARCINOGENIC PROPERTIES OF A SUBSTANCE
Title (en)
BIOLOGICAL ASSAY FOR TESTING THE CARCINOGENIC PROPERTIES OF A SUBSTANCE
Title (de)
BIOLOGISCHER ASSAY ZUM TESTEN KARZINOGENER EIGENSCHAFTEN EINER SUBSTANZ
Title (fr)
ANALYSE BIOLOGIQUE DESTINEE A ANALYSER LES PROPRIETES CANCEROGENES D'UNE SUBSTANCE
Publication
Application
Priority
- GB 9800869 W 19980408
- GB 9707141 A 19970408
Abstract (en)
[origin: WO9845476A1] An assay for testing the carcinogenic properties of a test substance comprising: (i) introducing into cells a reporter gene expression vector comprising a repetitive DNA sequence which exhibits instability in cancer cells, whereby instability of the repetitive DNA sequence affects expression of the reporter gene; (ii) exposing the resulting cells to the test substance; and (iii) determining whether the test substance is carcinogenic or anticarcinogenic by comparing the frequency of reporter gene expression in the resulting cells with the frequency of reporter gene expression in cells which have not been exposed to the test substance. The invention also provides expression vectors suitable for use in the assay methods.
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01); C12Q 1/6897 (2018.01); G01N 33/50 (2006.01)
CPC (source: EP)
C12Q 1/6897 (2013.01); G01N 33/5017 (2013.01)
Citation (search report)
See references of WO 9845476A1
Designated contracting state (EPC)
DE FR GB SE
DOCDB simple family (publication)
WO 9845476 A1 19981015; AU 7055698 A 19981030; EP 0973946 A1 20000126; GB 9707141 D0 19970528
DOCDB simple family (application)
GB 9800869 W 19980408; AU 7055698 A 19980408; EP 98917309 A 19980408; GB 9707141 A 19970408