Global Patent Index - EP 0974653 A2

EP 0974653 A2 2000-01-26 - Human gastric cancer antigen gene and protein

Title (en)

Human gastric cancer antigen gene and protein

Title (de)

Menschliches Gen und Protein eines Magenkrebs-Antigens

Title (fr)

Gène et protéine humaine d'un antigène du cancer de l'estomac

Publication

EP 0974653 A2 (EN)

Application

EP 99305469 A

Priority

JP 19785298 A

Abstract (en)

A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; C07K 7/06; C07K 14/47

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 3/02 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C07K 14/4748 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

EP 0974653 A2 20000126; EP 0974653 A3 20010919; EP 0974653 B1 20050914; AT 304593 T 20050915; DE 69927214 D1 20051020; DE 69927214 T2 20060706; JP 2000023673 A 20000125; US 2002173642 A1 20021121; US 6444800 B1 20020903; US 7030222 B2 20060418