Global Patent Index - EP 0975338 A2

EP 0975338 A2 2000-02-02 - 2,2'-BI-1H-PYRROLE DERIVATIVES USEFUL IN THE TREATMENT OF LEUKEMIA BROUGHT ON BY HTLV-I

Title (en)

2,2'-BI-1H-PYRROLE DERIVATIVES USEFUL IN THE TREATMENT OF LEUKEMIA BROUGHT ON BY HTLV-I

Title (de)

2, 2' -BI-1H-PYRROLE DERIVATEN ZUR BEHANDLUNG VON HTLV-I-VERURSACHTEN LEUKEMIEN

Title (fr)

DERIVES DE 2,2'-BI-1H-PYRROLE UTILISES POUR TRAITER LA LEUCEMIE PROVOQUEE PAR LE VIRUS HTLV-1

Publication

EP 0975338 A2 (EN)

Application

EP 98965212 A

Priority

  • EP 9807774 W
  • GB 9726130 A

Abstract (en)

[origin: WO9929309A2] The use of a compound which is a 2,2'-bi-1H-pyrrole of formula (I) wherein R1 is hydrogen, phenyl, C1-C20 alkyl or C2-C20 alkenyl, wherein the alkyl and alkenyl groups are unsubstituted or substituted by 1 to 3 substituents; R2 is hydrogen, C1-C6 alkyl, cyano, carboxy or (C1-C6 alkoxy)carbonyl; R3 is halogen, hydroxy or C1-C11 alkoxy unsubstituted or substituted by phenyl; R4 represent hydrogen, C1-C6 alkyl or phenyl; each of R5 and R6, which are the same or different, independently represents hydrogen, C2-C20 alkanoyl, C3-C20 alkenoyl, phenyl, C1-C20 alkyl or C2-C20 alkenyl, wherein the alkanoyl, alkenoyl, alkyl and the alkenyl groups are unsubstituted or substituted by 1 to 3 substituents; or two of R4, R5 and R6 taken together form a C4-C12 polymethylene chain, which is unsubstituted or substituted by C1-C12 alkyl, C2-C12 alkenyl or C1-C12 alkylidene; or pharmaceutically acceptable salt thereof; in the preparation of a medicament for use in the treatment of adult-T-cell leukemia-lymphoma, in particular brought on by infection with HTLV-I.

IPC 1-7 (main, further and additional classification)

A61K 31/00

IPC 8 full level (invention and additional information)

C07D 207/44 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/404 (2006.01); A61K 31/535 (2006.01); A61P 35/02 (2006.01)

CPC (invention and additional information)

A61K 31/5377 (2013.01); A61K 31/40 (2013.01); A61K 31/4025 (2013.01); A61K 31/404 (2013.01); A61K 31/535 (2013.01)

Combination set (CPC)

  1. A61K 31/40 + A61K 2300/00
  2. A61K 31/535 + A61K 2300/00

Citation (search report)

See references of WO 9929309A3

Designated contracting state (EPC)

DE ES FR GB IT SE

EPO simple patent family

WO 9929309 A2 19990617; WO 9929309 A3 19990722; EP 0975338 A2 20000202; GB 9726130 D0 19980211; JP 2001511191 A 20010807

INPADOC legal status


2006-05-03 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051025

2002-06-12 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: PHARMACIA ITALIA S.P.A.

2002-05-22 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020404

2000-02-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990629

2000-02-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): DE ES FR GB IT SE