EP 0975370 B9 20040908 - ZUSAMMENSETZUNG UND VERFAHREN ZUR VERZÖGERUNG DES TRANSPORTS DURCH BIOLOGISCHE MEMBRANEN
Title (de)
ZUSAMMENSETZUNG UND VERFAHREN ZUR VERZÖGERUNG DES TRANSPORTS DURCH BIOLOGISCHE MEMBRANEN
Publication
Application
Priority
- US 9810571 W 19980521
- US 4734597 P 19970521
Abstract (en)
[origin: US2006111274A1] Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention pertains to a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In a preferred embodiment, the polymer consists of from 6 to 25 subunits, at least 50% of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form.
IPC 1-7
IPC 8 full level
A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07B 61/00 (2006.01); C07D 305/14 (2006.01)
CPC (source: EP KR US)
A61K 31/785 (2013.01 - EP KR US); A61K 47/62 (2017.08 - EP US); A61K 47/645 (2017.08 - EP US); A61K 48/00 (2013.01 - KR); A61P 43/00 (2018.01 - EP); C07D 305/14 (2013.01 - EP KR US); C40B 40/00 (2013.01 - KR); A61K 48/00 (2013.01 - EP US); C07B 2200/11 (2013.01 - EP KR US); C40B 40/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9852614 A2 19981126; WO 9852614 A3 19990318; AT E251913 T1 20031115; AU 734827 B2 20010621; AU 7593898 A 19981211; BR 9809138 A 20010828; CA 2291074 A1 19981126; CA 2291074 C 20080401; CN 1263473 A 20000816; DE 69818987 D1 20031120; DE 69818987 T2 20040729; EP 0975370 A2 20000202; EP 0975370 B1 20031015; EP 0975370 B9 20040908; EP 0975370 B9 20041103; ES 2210761 T3 20040701; GB 2341390 A 20000315; GB 2341390 B 20001108; GB 9923841 D0 19991208; IL 132941 A0 20010319; JP 2002502376 A 20020122; KR 20010012809 A 20010226; PL 337033 A1 20000731; US 2002131965 A1 20020919; US 2003162719 A1 20030828; US 2006111274 A1 20060525; US 6306993 B1 20011023; US 6495663 B1 20021217
DOCDB simple family (application)
US 9810571 W 19980521; AT 98923711 T 19980521; AU 7593898 A 19980521; BR 9809138 A 19980521; CA 2291074 A 19980521; CN 98807186 A 19980521; DE 69818987 T 19980521; EP 98923711 A 19980521; ES 98923711 T 19980521; GB 9923841 A 19980521; IL 13294198 A 19980521; JP 55071698 A 19980521; KR 19997010772 A 19991120; PL 33703398 A 19980521; US 33500706 A 20060118; US 33834803 A 20030107; US 39619599 A 19990914; US 8325998 A 19980521; US 95716101 A 20010919