EP 0975371 A1 20000202 - ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF ACTIVATING PROTEIN 1
ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF ACTIVATING PROTEIN 1
ANTISENSE OLIGONUKLEOTIDZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION DES AKTIVIERENDEN PROTEINS 1.
COMPOSITIONS D'OLIGONUCLEOTIDES ANTISENS ET PROCEDES DE MODULATION DE LA PROTEINE 1 D'ACTIVATION
- US 9807386 W
- US 83720197 A
[origin: WO9846272A1] Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.
IPC 8 full level
CPC (source: EP)
C12N 15/1135 (2013.01); A61K 38/00 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3181 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/33 (2013.01); C12N 2310/334 (2013.01); C12N 2310/335 (2013.01)
C-Set (source: EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DOCDB simple family (application)
US 9807386 W 19980414; AU 6968898 A 19980414; EP 98915526 A 19980414; US 36441699 A 19990730; US 43019603 A 20030505; US 83720197 A 19970414; US 92351701 A 20010807