EP 0975606 A1 20000202 - CRAMBESCIDIN COMPOUNDS
Title (en)
CRAMBESCIDIN COMPOUNDS
Title (de)
CRAMBESCIDIN-VERBINDUNGEN
Title (fr)
COMPOSES DE CRAMBESCIDINE
Publication
Application
Priority
- US 9807644 W 19980414
- US 4332797 P 19970415
Abstract (en)
[origin: WO9846575A1] Together with the know crambescidins (1-5) and ptilomycalin A (6), two new minor crambescidins 834 (7), 818 (8) with a chlorinated spermidine unit and four new minor crambescidins 673 (9), 687 (10), 657 (11) and 13, 14, 15-isocrambescidin 657 (12) without a spermidine derivative unit have been obtained by FABMS guided isolation from extracts of the Mediterranean sponge Crambe crambe. Their structures were elucidated by interpretation of spectral data (see Figures 4-9). In a parallel bioassay against L1210 murine leukemia cells, crambescidins 834 (7), 818 (8) and 657 (11) were shown to be five times as cytotoxic as the knows crambescidin 816 (1). Crambescidins with a spermidine or spermidine derivative unit also exhibited antimicrobial activity against Rhodotorula glutinis.
IPC 1-7
IPC 8 full level
A01N 43/90 (2006.01); A61K 31/527 (2006.01); A61P 35/00 (2006.01); C07D 491/22 (2006.01)
CPC (source: EP KR US)
A01N 43/90 (2013.01 - EP US); A61P 35/00 (2018.01 - EP); C07D 239/00 (2013.01 - KR); C07D 491/22 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9846575 A1 19981022; AU 7124198 A 19981111; AU 752529 B2 20020919; BR 9808905 A 20000801; CA 2286738 A1 19981022; CN 1259938 A 20000712; EP 0975606 A1 20000202; EP 0975606 A4 20020612; HU P0003765 A2 20010528; HU P0003765 A3 20020729; IL 132402 A0 20010319; JP 2002516609 A 20020604; KR 20010006403 A 20010126; NO 313637 B1 20021104; NO 995015 D0 19991014; NO 995015 L 19991116; PL 336307 A1 20000619; US 6028077 A 20000222
DOCDB simple family (application)
US 9807644 W 19980414; AU 7124198 A 19980414; BR 9808905 A 19980414; CA 2286738 A 19980414; CN 98806080 A 19980414; EP 98918287 A 19980414; HU P0003765 A 19980414; IL 13240298 A 19980414; JP 54427698 A 19980414; KR 19997009490 A 19991015; NO 995015 A 19991014; PL 33630798 A 19980414; US 5850798 A 19980410