EP 0975612 A1 20000202 - PROTEASE INHIBITORS
Title (en)
PROTEASE INHIBITORS
Title (de)
PROTEASEINHIBITOREN
Title (fr)
INHIBITEURS DE PROTEASES
Publication
Application
Priority
- US 9807969 W 19980415
- US 4309697 P 19970415
- US 4453197 P 19970423
Abstract (en)
[origin: WO9846582A1] This invention relates to compounds of formula (I) wherein: X, Y and Z independently are N, O, S or CR', provided that at least two of X, Y and Z are heteroatoms and at least one of X, Y and Z is N; or one of X, Y and Z is C=N, C=C or N=N and the other two are CR' or N, provided that X, Y and Z together comprise at least two N; <u>---</u> indicates a single or double bond; R<1> is R'', R''C(O), R''C(S), R''SO2, R''OC(O), or R''OC(O)NR'CH(R<6>)C(O); R<2> is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<3> is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<4> is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<5> is C1-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, CH(R<6>)NR'R<7>, CH(R<6>)Ar, CH(R<6>)OAr, or NR<8>R<9>; R6, R7, R8 and R9 are as defined in the description; R<10> is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof, which are inhibitors of cysteine porteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor.
IPC 1-7
IPC 8 full level
A61K 31/427 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61P 1/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP)
A61P 1/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 29/00 (2017.12); A61P 43/00 (2017.12); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07K 5/06139 (2013.01)
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9846582 A1 19981022; AR 012374 A1 20001018; AU 7252398 A 19981111; CA 2285601 A1 19981022; CO 4950541 A1 20000901; EP 0975612 A1 20000202; EP 0975612 A4 20010613; JP 2002515902 A 20020528
DOCDB simple family (application)
US 9807969 W 19980415; AR P980101627 A 19980408; AU 7252398 A 19980415; CA 2285601 A 19980415; CO 98020566 A 19980415; EP 98919821 A 19980415; JP 54437598 A 19980415