Global Patent Index - EP 0975612 A1

EP 0975612 A1 2000-02-02 - PROTEASE INHIBITORS

Title (en)

PROTEASE INHIBITORS

Title (de)

PROTEASEINHIBITOREN

Title (fr)

INHIBITEURS DE PROTEASES

Publication

EP 0975612 A1 (EN)

Application

EP 98919821 A

Priority

  • US 9807969 W
  • US 4309697 P
  • US 4453197 P

Abstract (en)

[origin: WO9846582A1] This invention relates to compounds of formula (I) wherein: X, Y and Z independently are N, O, S or CR', provided that at least two of X, Y and Z are heteroatoms and at least one of X, Y and Z is N; or one of X, Y and Z is C=N, C=C or N=N and the other two are CR' or N, provided that X, Y and Z together comprise at least two N; <u>---</u> indicates a single or double bond; R<1> is R'', R''C(O), R''C(S), R''SO2, R''OC(O), or R''OC(O)NR'CH(R<6>)C(O); R<2> is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<3> is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<4> is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or Het-C0-6alkyl; R<5> is C1-6alkyl, Ar-C0-6alkyl, Het-C0-6alkyl, CH(R<6>)NR'R<7>, CH(R<6>)Ar, CH(R<6>)OAr, or NR<8>R<9>; R6, R7, R8 and R9 are as defined in the description; R<10> is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof, which are inhibitors of cysteine porteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor.

IPC 1-7 (main, further and additional classification)

C07D 277/04

IPC 8 full level (invention and additional information)

A61K 31/427 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61P 1/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07K 5/078 (2006.01)

CPC (invention and additional information)

C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07K 5/06139 (2013.01)

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9846582 A1 19981022; AR 012374 A1 20001018; AU 7252398 A 19981111; CA 2285601 A1 19981022; CO 4950541 A1 20000901; EP 0975612 A1 20000202; EP 0975612 A4 20010613; JP 2002515902 A 20020528

INPADOC legal status


2002-02-27 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010730

2001-06-13 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010502

2001-06-13 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL

2001-06-13 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7C 07D 417/12 A, 7C 07D 417/14 B, 7C 07K 5/06 B, 7A 61K 31/425 B, 7A 61K 31/47 B, 7A 61K 38/05 B

2000-02-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991108

2000-02-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL