Global Patent Index - EP 0975628 A4

EP 0975628 A4 2001-03-21 - PREVENTION OF BREAST CANCER WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS

Title (en)

PREVENTION OF BREAST CANCER WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS

Title (de)

VORBEUGUNG VON BRUSTKREBS MIT HILFE EINES SELEKTIVEN MODULATORS DES ÖSTROGEN-REZEPTORS

Title (fr)

PROPHYLAXIE DU CARCINOME MAMMAIRE AU MOYEN DE MODULATEURS SELECTIFS DU RECEPTEUR DES OESTROGENES

Publication

EP 0975628 A4 (EN)

Application

EP 98915368 A

Priority

  • US 9806989 W
  • US 4311897 P

Abstract (en)

[origin: WO9845286A1] The present invention provides a method of preventing breast carcinoma or cancer in a patient comprising administering a therapeutically effective amount of a compound having the structure (I) in which R<1> and R<2> are independently hydroxy or alkoxy of one to four carbon atoms; and R<3> and R<4> are independently methyl or ethyl, or R<3> and R<4>, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.

IPC 1-7 (main, further and additional classification)

C07D 409/12; A61K 31/38; A61K 31/445; A61K 31/535

IPC 8 full level (invention and additional information)

A61K 31/4025 (2006.01); A61K 31/4535 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61P 35/00 (2006.01); C07D 333/64 (2006.01)

CPC (invention and additional information)

C07D 333/64 (2013.01); A61K 31/4535 (2013.01)

Citation (search report)

  • [Y] FUCHS-YOUNG ET AL: "Preclinical demonstration of specific and potent inhibition of mammary tumor growth by new selective estrogen receptor modulators (SERMs", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH,US,PHILADELPHIA, AACR, vol. 38, March 1997 (1997-03-01), pages 573, XP002111820
  • [Y] TERMINE JOHN D: "Raloxifene HCL: A tissue selective estrogen receptor modifier (SERM) for replacement therapy in postmenopausal women.", WOMEN'S HEALTH AND MENOPAUSE: RISK REDUCTION STRATEGIES., 2nd International Symposium on Women's Health in Menopause;Florence, Italy; December 5-8, 1996, Kluwer Law International;Kluwer Academic Publishers P. O. Box 85889, 2508, The Hague, Netherlands; 101 P, pages 315 - 320, XP000973248, ISBN: 0-7923-4697-1
  • [A] MASAHIKO SATO ET AL: "RALOXIFENE: A SELECTIVE ESTROGEN RECEPTOR MODULATOR", JOURNAL OF BONE AND MINERAL METOBOLISM,XX,XX, vol. 12, no. SUPPL. 02, 1994, pages S09 - S20, XP000564019
  • See also references of WO 9845286A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9845286 A1 19981015; AU 6957398 A 19981030; CA 2286207 A1 19981015; CN 1259945 A 20000712; EA 199900910 A1 20000424; EP 0975628 A1 20000202; EP 0975628 A4 20010321; HU 0001845 A2 20010628; ID 23653 A 20000511; IL 132279 D0 20010319; JP 2001518897 A 20011016; KR 20010006215 A 20010126; NO 994902 A 19991207; NO 994902 D0 19991008; PL 336206 A1 20000605; TR 9903244 T2 20000522; ZA 9802818 B 19991004

INPADOC legal status


2003-05-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021104

2001-03-21 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010205

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-03-21 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 07D 409/12 A, 7A 61K 31/535 B, 7A 61K 31/38 B, 7A 61K 31/445 B

2000-02-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991015

2000-02-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-02-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19991015;LT PAYMENT 19991015;LV PAYMENT 19991015;RO PAYMENT 19991015;SI PAYMENT 19991015