Global Patent Index - EP 0975662 A1

EP 0975662 A1 20000202 - HEPATITIS C NS3 PROTEASE INHIBITORS

Title (en)

HEPATITIS C NS3 PROTEASE INHIBITORS

Title (de)

HEPATITIS C NS3 PROTEASE INHIBITORE

Title (fr)

INHIBITEURS DE PROTEASE NS3 POUR L'HEPATITE C

Publication

EP 0975662 A1 (EN)

Application

EP 98917395 A

Priority

  • GB 9801126 W
  • GB 9707659 A

Abstract (en)

[origin: WO9846630A1] Disclosed is a specific pharmacophoric profile which represents the structure for inhibitors of Hepatitis C NS3 protease. The results from mapping studies of the enzyme with depsipeptide substrates allow the generation of a particular pharmacophoric binding profile. Compounds possessing this motif were shown to be inhibitors of Hepatitis NS3 protease. The inhibitors have use in the treatment of hepatitis C.

IPC 1-7

C07K 5/113; A61K 38/07

IPC 8 full level

A61K 38/55 (2006.01); A61P 1/16 (2006.01); A61P 31/12 (2006.01); C07K 5/113 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 1/16 (2018.01); A61P 31/12 (2018.01); C07K 5/1021 (2013.01); A61K 38/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9846630 A1 19981022; AU 7063598 A 19981111; EP 0975662 A1 20000202; GB 9707659 D0 19970604; JP 2001521516 A 20011106

DOCDB simple family (application)

GB 9801126 W 19980416; AU 7063598 A 19980416; EP 98917395 A 19980416; GB 9707659 A 19970416; JP 54364898 A 19980416