EP 0975750 A2 20000202 - MODIFIED RETINOBLASTOMA TUMOR SUPPRESSOR PROTEINS

Title (en)

MODIFIED RETINOBLASTOMA TUMOR SUPPRESSOR PROTEINS

Title (de)

MODIFIZIERTE RETINOBLASTOMA TUMORSUPPRESSOR-PROTEINE

Title (fr)

PROTEINES MODIFIEES DE SUPPRESSION DES RETINOBLASTOMES

Publication

EP 0975750 A2 20000202 (EN)

Application

EP 98908570 A 19980219

Priority

US 9803041 W 19980219
US 3811897 P 19970220

Abstract (en)

[origin: WO9837091A2] Disclosed are modified broad-spectrum retinoblastoma tumor suppressor proteins that have at least the same, and in most cases higher biological activity than the corresponding wild-type retinoblastoma tumor suppressor protein. Exemplary modified retinoblastoma tumor suppressor proteins have a modified N-terminal region, in particular comprising one or more deletions and/or mutations. Also disclosed are methods of making and using the modified retinoblastoma tumor suppressor proteins, particularly in circumstances where inhibition of cell growth is desired. Thus the present disclosure provides methods for treating diseases, as exemplified by, but not limited to cancer, that are characterized by abnormal cellular proliferation.

IPC 1-7

C12N 15/12; C07K 14/47; A61K 31/70; A61K 38/17; C12N 5/10

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP KR)

A61P 35/00 (2017.12 - EP); C07K 14/4736 (2013.01 - EP); C12N 15/11 (2013.01 - KR); A01K 2217/05 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 48/00 (2013.01 - EP); C12N 2799/022 (2013.01 - EP)

Citation (search report)

See references of WO 9837091A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9837091 A2 19980827; WO 9837091 A3 19981105; AU 6657398 A 19980909; CA 2281899 A1 19980827; CN 1259998 A 20000712; EP 0975750 A2 20000202; IL 131496 A0 20010128; JP 2001512325 A 20010821; KR 20000075501 A 20001215

DOCDB simple family (application)

US 9803041 W 19980219; AU 6657398 A 19980219; CA 2281899 A 19980219; CN 98802742 A 19980219; EP 98908570 A 19980219; IL 13149698 A 19980219; JP 53678898 A 19980219; KR 19997007560 A 19990820