Global Patent Index - EP 0977595 A1

EP 0977595 A1 2000-02-09 - PREVENTION OF GRAFT-VERSUS-HOST DISEASE WITH T-CELLS INCLUDING POLYNUCLEOTIDES ENCODING NEGATIVE SELECTIVE MARKERS

Title (en)

PREVENTION OF GRAFT-VERSUS-HOST DISEASE WITH T-CELLS INCLUDING POLYNUCLEOTIDES ENCODING NEGATIVE SELECTIVE MARKERS

Title (de)

VERHÜTUNG VON TRANSPLANTAT/EMPFÄNGER KRANKHEITEN MITTELS T-ZELLEN, WELCHE POLYNUKLEINSÄUREN FÜR NEGATIVE SELEKTIONSMARKER BEINHALTEN

Title (fr)

PREVENTION DE LA REACTION DU GREFFON CONTRE L'HOTE AU MOYEN DE LYMPHOCYTES THYMO-DEPENDANTS CONTENANT DES POLYNUCLEOTIDES CODANT DES MARQUEURS DE SELECTION NEGATIVE

Publication

EP 0977595 A1 (EN)

Application

EP 97925747 A

Priority

  • US 9709040 W
  • US 65645196 A

Abstract (en)

[origin: WO9745142A1] A method of preventing graft-versus-host disease in a patient being treated for relapsed or persistent leukemia. The method comprises administering to a host allogeneic T-cells genetically engineered to include a polynucleotide encoding a negative selective marker. Prior to the occurrence of graft-versus-host disease, an interaction or chemotherapeutic agent is administered to the host, which kills the genetically engineered T-cells, thereby preventing the occurrence of graft-versus-host disease. Such method also may be employed in connection with the treatment of any disease or disorder wherein the treatment includes bone marrow ablation followed by the administration of a T-cell depleted bone marrow transplant.

IPC 1-7 (main, further and additional classification)

A61K 48/00; C12N 15/09; C12N 15/85

IPC 8 full level (invention and additional information)

A61K 48/00 (2006.01); A61K 31/00 (2006.01); A61K 31/52 (2006.01); A61K 31/522 (2006.01); A61K 35/14 (2006.01); A61K 35/26 (2006.01); A61K 35/76 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C12N 15/08 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

A61K 39/001 (2013.01); A61K 31/522 (2013.01); A61K 35/17 (2013.01); A61K 35/28 (2013.01); A61K 45/06 (2013.01); A61K 2039/5156 (2013.01)

Combination set (CPC)

A61K 31/522 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9745142 A1 19971204; AU 3079697 A 19980105; AU 719930 B2 20000518; CA 2255941 A1 19971204; EP 0977595 A1 20000209; EP 0977595 A4 20010516; IL 127211 D0 19990922; JP 2000511539 A 20000905; NO 985522 A 19990125; NO 985522 D0 19981126; NZ 333053 A 20000623

INPADOC legal status


2002-01-23 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20010614

2001-05-16 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010403

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-02-09 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19981218

2000-02-09 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-02-09 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: RO PAYMENT 19981218;SI PAYMENT 19981218