Title (en)

PREVENTION OF GRAFT-VERSUS-HOST DISEASE WITH T-CELLS INCLUDING POLYNUCLEOTIDES ENCODING NEGATIVE SELECTIVE MARKERS

Title (de)

VERHÜTUNG VON TRANSPLANTAT/EMPFÄNGER KRANKHEITEN MITTELS T-ZELLEN, WELCHE POLYNUKLEINSÄUREN FÜR NEGATIVE SELEKTIONSMARKER BEINHALTEN

Title (fr)

PREVENTION DE LA REACTION DU GREFFON CONTRE L'HOTE AU MOYEN DE LYMPHOCYTES THYMO-DEPENDANTS CONTENANT DES POLYNUCLEOTIDES CODANT DES MARQUEURS DE SELECTION NEGATIVE

Publication

EP 0977595 A1 20000209 (EN)

Application

EP 97925747 A 19970528

Priority

• US 9709040 W 19970528
• US 65645196 A 19960531

Abstract (en)

[origin: WO9745142A1] A method of preventing graft-versus-host disease in a patient being treated for relapsed or persistent leukemia. The method comprises administering to a host allogeneic T-cells genetically engineered to include a polynucleotide encoding a negative selective marker. Prior to the occurrence of graft-versus-host disease, an interaction or chemotherapeutic agent is administered to the host, which kills the genetically engineered T-cells, thereby preventing the occurrence of graft-versus-host disease. Such method also may be employed in connection with the treatment of any disease or disorder wherein the treatment includes bone marrow ablation followed by the administration of a T-cell depleted bone marrow transplant.

IPC 1-7

A61K 48/00; C12N 15/09; C12N 15/85

IPC 8 full level

A61K 48/00 (2006.01); A61K 31/00 (2006.01); A61K 31/52 (2006.01); A61K 31/522 (2006.01); A61K 35/14 (2006.01); A61K 35/17 (2015.01); A61K 35/26 (2006.01); A61K 35/28 (2015.01); A61K 35/76 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C12N 15/08 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61K 31/522 (2013.01); A61K 35/28 (2013.01); A61K 39/001 (2013.01); A61K 39/4611 (2023.05); A61K 39/4644 (2023.05); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05)

C-Set (source: EP)

A61K 31/522 + A61K 2300/00

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9745142 A1 19971204; AU 3079697 A 19980105; AU 719930 B2 20000518; CA 2255941 A1 19971204; EP 0977595 A1 20000209; EP 0977595 A4 20010516; IL 127211 A0 19990922; JP 2000511539 A 20000905; NO 985522 D0 19981126; NO 985522 L 19990125; NZ 333053 A 20000623

DOCDB simple family (application)

US 9709040 W 19970528; AU 3079697 A 19970528; CA 2255941 A 19970528; EP 97925747 A 19970528; IL 12721197 A 19970528; JP 54288997 A 19970528; NO 985522 A 19981126; NZ 33305397 A 19970528