EP 0977717 A1 20000209 - PRODUCTION OF ENANTIOMER-FREE BIARYLKETOCARBOXYLIC ACIDS
Title (en)
PRODUCTION OF ENANTIOMER-FREE BIARYLKETOCARBOXYLIC ACIDS
Title (de)
HERSTELLUNG ENANTIOMERENREINER BIARYLKETOCARBONSÄUREN
Title (fr)
PREPARATION D'ACIDES BIARYLCETOCARBOXYLIQUES EXEMPTS D'ENANTIOMERES
Publication
Application
Priority
- DE 19717429 A 19970425
- EP 9802176 W 19980414
Abstract (en)
[origin: WO9849124A1] The invention relates to a novel method for producing enantiomer-free biarylketocarboxylic acids, whereby S-phenylethylamine is used as an auxiliary base in racemate resolution. Biarylketocarboxylic acids, specially substituted biaryl-4-ketocarboxylic acids, are inhibitors for enzymes of the matrix-metallo-proteinase class. Osteoarthritis, rheumatoid arthritis and metastases can, for instance, be combated by inhibiting the above-mentioned enzymes.
IPC 1-7
IPC 8 full level
C07B 57/00 (2006.01); C07C 319/28 (2006.01); C07C 323/56 (2006.01)
CPC (source: EP KR US)
C07B 57/00 (2013.01 - EP KR US); C07C 319/28 (2013.01 - EP US)
C-Set (source: EP US)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9849124 A1 19981105; AR 012440 A1 20001018; AU 730250 B2 20010301; AU 7525198 A 19981124; BG 103776 A 20000531; BR 9809418 A 20000613; CA 2288107 A1 19981105; CN 1253539 A 20000517; CO 4940428 A1 20000724; DE 19717429 A1 19981224; EP 0977717 A1 20000209; HU P0003633 A2 20010328; HU P0003633 A3 20010428; ID 22701 A 19991209; IL 132065 A0 20010319; JP 2001524102 A 20011127; KR 20010020236 A 20010315; NO 994977 D0 19991013; NO 994977 L 19991013; PL 336323 A1 20000619; SK 145999 A3 20000516; TR 199902451 T2 20000421; TW 382622 B 20000221; US 6172259 B1 20010109; ZA 983473 B 19981029
DOCDB simple family (application)
EP 9802176 W 19980414; AR P980101737 A 19980415; AU 7525198 A 19980414; BG 10377699 A 19991004; BR 9809418 A 19980414; CA 2288107 A 19980414; CN 98804521 A 19980414; CO 98022781 A 19980424; DE 19717429 A 19970425; EP 98922707 A 19980414; HU P0003633 A 19980414; ID 991186 A 19980414; IL 13206598 A 19980414; JP 54653698 A 19980414; KR 19997009828 A 19991023; NO 994977 A 19991013; PL 33632398 A 19980414; SK 145999 A 19980414; TR 9902451 T 19980414; TW 87104934 A 19980402; US 38159799 A 19990920; ZA 983473 A 19980424