Global Patent Index - EP 0977743 A1

EP 0977743 A1 2000-02-09 - PROTEASE INHIBITORS

Title (en)

PROTEASE INHIBITORS

Title (de)

PROTEASE-INHIBITOREN

Title (fr)

INHIBITEURS DE PROTEASES

Publication

EP 0977743 A1 (EN)

Application

EP 98918482 A

Priority

  • US 9807942 W
  • US 4490697 P

Abstract (en)

[origin: WO9849152A1] Compounds of formula (I), wherein R<l> is an aromatic or a heteroaromatic ring; R<2> and R<3> are H, C1-C8alkyl, aryl, arylC1-C8alkyl, or heteroaryl; R<4> is an aromatic or a heteroaromatic ring or an amine; W, X, Y, are independently selected from the group consisting of CH, N, S, or O, provided that at least one of W, X, and Y is a heteroatom, which inhibit protease, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease therewith.

IPC 1-7 (main, further and additional classification)

C07D 277/32; A61K 31/425

IPC 8 full level (invention and additional information)

C07D 277/20 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61P 1/02 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 43/285 (2006.01); C07C 43/295 (2006.01); C07C 65/24 (2006.01); C07C 69/92 (2006.01); C07C 205/26 (2006.01); C07C 205/37 (2006.01); C07C 217/90 (2006.01); C07C 235/28 (2006.01); C07C 243/22 (2006.01); C07C 335/26 (2006.01); C07D 215/18 (2006.01); C07D 215/227 (2006.01); C07D 215/38 (2006.01); C07D 277/32 (2006.01); C07D 277/56 (2006.01); C07D 417/12 (2006.01); C07F 5/02 (2006.01); C07D 215/22 (2006.01)

CPC (invention and additional information)

C07D 215/227 (2013.01); C07C 43/285 (2013.01); C07C 43/295 (2013.01); C07C 65/24 (2013.01); C07C 69/92 (2013.01); C07C 205/26 (2013.01); C07C 205/37 (2013.01); C07C 217/90 (2013.01); C07C 235/28 (2013.01); C07C 243/22 (2013.01); C07C 335/26 (2013.01); C07D 215/18 (2013.01); C07D 215/38 (2013.01); C07D 277/56 (2013.01); C07D 417/12 (2013.01); C07F 5/025 (2013.01)

Citation (search report)

See references of WO 9849152A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9849152 A1 19981105; AR 012603 A1 20001108; AU 7139598 A 19981124; CA 2287567 A1 19981105; CO 4950567 A1 20000901; EP 0977743 A1 20000209; JP 2002501502 A 20020115; MA 26486 A1 20041220; PE 68599 A1 19990926; ZA 9808479 B 19981026

INPADOC legal status


2003-05-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021101

2000-02-09 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991119

2000-02-09 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE ES FR GB IT LI NL