Global Patent Index - EP 0977775 A2

EP 0977775 A2 20000209 - USE OF A NOVEL DISINTEGRIN METALLOPROTEASE, MUTANTS, FRAGMENTS AND THE LIKE

Title (en)

USE OF A NOVEL DISINTEGRIN METALLOPROTEASE, MUTANTS, FRAGMENTS AND THE LIKE

Title (de)

VERWENDUNG EINER NEUEN DISINTEGRIN METALLOPROTEASE

Title (fr)

UTILISATION D'UNE NOUVELLE PROTEINE METALLOPROTEASE DISINTEGRINE, MUTANTS, FRAGMENTS ET ANALOGUES DE LADITE PROTEINE

Publication

EP 0977775 A2 20000209 (EN)

Application

EP 98906648 A 19980225

Priority

  • US 9803490 W 19980225
  • US 81015397 A 19970225
  • US 9703217 W 19970228

Abstract (en)

[origin: WO9837092A2] This invention provides a method for identifying compounds capable of binding to the disintegrin protein, and determining the amount and affinity of a compound capable of binding to the disintegrin protein in a sample. This invention also provides a host cell comprising a recombinant expression vector to the disintegrin protein and a recombinant expression vector encoding to the disintegrin protein and the human disentegrin metalloprotease protein, fragment or mutant thereof, useful for these purposes. This invention also provides an in vivo or in vitro method for screening for osteoarthritis and other metalloprotease based diseases, capable of manufacture and use in a kit form.

IPC 1-7

C07K 14/00; C12Q 1/68

IPC 8 full level

C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12Q 1/37 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01)

CPC (source: EP)

C12N 9/6489 (2013.01)

Citation (search report)

See references of WO 9837092A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9837092 A2 19980827; WO 9837092 A3 19981105; AU 6181798 A 19980909; CA 2281085 A1 19980827; EP 0977775 A2 20000209; HU 0100780 A2 20010628; JP 2001514494 A 20010911; NO 994056 D0 19990823; NO 994056 L 19991025

DOCDB simple family (application)

US 9803490 W 19980225; AU 6181798 A 19980225; CA 2281085 A 19980225; EP 98906648 A 19980225; HU 0100780 A 19980225; JP 53694698 A 19980225; NO 994056 A 19990823