Global Patent Index - EP 0977847 A1

EP 0977847 A1 2000-02-09 - BRCA2 TRANSCRIPTIONAL ACTIVATOR DOMAIN AND USES THEREOF

Title (en)

BRCA2 TRANSCRIPTIONAL ACTIVATOR DOMAIN AND USES THEREOF

Title (de)

TRANSKRIPTIONSAKTIVIERUNGSDOMÄN VON BRCA2 UND DESSEN VERWENDUNGEN

Title (fr)

DOMAINE DE L'ACTIVATEUR TRANSCRIPTIONNEL DE BRCA2 ET SES UTILISATIONS

Publication

EP 0977847 A1 (EN)

Application

EP 98917445 A

Priority

  • GB 9801181 W
  • GB 9708221 A

Abstract (en)

[origin: WO9848013A1] Exon 3 of BRCA2 encodes a transcriptional activator domain ("TAD"), including a primary activating region ("PAR") and an auxiliary activating region ("AAR"), flanked by two inhibitory regions ("IR1" and "IR2") which are bound by molecules which inhibit activation of transcription by the TAD. Appropriate fragments of BRCA2 polypeptide are useful in activating transcription and in assays for substances able to modulate transcriptional activation by BRCA2.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; C07K 14/47; C07K 14/82; C12N 5/10; C12N 15/62; C12Q 1/48; C12Q 1/68; G01N 33/50

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/82 (2013.01); C07K 14/4702 (2013.01); C07K 14/4705 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9848013A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9848013 A1 19981029; AU 7067498 A 19981113; CA 2288335 A1 19981029; EP 0977847 A1 20000209; GB 9708221 D0 19970611

INPADOC legal status


2001-11-14 [18W] WITHDRAWN

- Date of withdrawal: 20010920

2000-08-16 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KOUZARIDES, TONY

2000-08-16 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LUKE TOBIT HUGHES-DAVIS

2000-02-09 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991115

2000-02-09 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE