EP 0977855 A2 20000209 - POLYPEPTIDES ASSOCIATED WITH ACTIVATOR RECEPTORS AND THEIR BIOLOGICAL APPLICATIONS
Title (en)
POLYPEPTIDES ASSOCIATED WITH ACTIVATOR RECEPTORS AND THEIR BIOLOGICAL APPLICATIONS
Title (de)
POLYPEPTIDE ASSOZIIERT MIT AKTIVATORREZEPTOREN UND DEREN BIOLOGISCHE ANWENDUNGEN
Title (fr)
POLYPEPTIDES ASSOCIES A DES RECEPTEURS ACTIVATEURS ET LEURS APPLICATIONS BIOLOGIQUES
Publication
Application
Priority
- FR 9800883 W 19980430
- FR 9705411 A 19970430
- FR 9800927 A 19980128
Abstract (en)
[origin: WO9849292A2] The invention concerns novel means for diagnosing, preventing, compensating, treating an abnormal or unwanted functioning of KAR receptors (Killer cell Activatory Receptor), counterparts of non-inhibiting KIR receptors (Killer cell Inhibitory Receptors) of the immunoglobulin or lectin type. The invention concerns, in particular, novel KARAP (KAR-Associated Proteins) polypeptides and their biological applications. A KARAP polypeptide is naturally associated with a KAR receptor, and in the absence of such a KARAP, said KAR receptor is naturally incapable of transducing an activating signal that can be detected. The application also concerns methods for obtaining or identifying such KARAP polypeptides.
IPC 1-7
C12N 15/12; C07K 14/705; C07K 16/28; C07K 1/36; G01N 33/53; G01N 33/577; G01N 33/68; A61K 38/17; A61K 39/395; C12Q 1/68
IPC 8 full level
A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP US)
A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/70503 (2013.01 - EP US); C07K 16/2803 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9849292A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9849292 A2 19981105; WO 9849292 A3 19990527; CA 2287916 A1 19981105; EP 0977855 A2 20000209; JP 2002503094 A 20020129; JP 2009005699 A 20090115; US 2005130130 A1 20050616; US 7569666 B2 20090804
DOCDB simple family (application)
FR 9800883 W 19980430; CA 2287916 A 19980430; EP 98921586 A 19980430; JP 2008153485 A 20080611; JP 54668798 A 19980430; US 90288604 A 20040802