Global patent index - EP 0977885 A1

EP 0977885 A1 2000-02-09 - METHODS FOR IDENTIFYING, CHARACTERIZING, AND EVOLVING CELL-TYPE SPECIFIC CIS REGULATORY ELEMENTS

Title (en)

METHODS FOR IDENTIFYING, CHARACTERIZING, AND EVOLVING CELL-TYPE SPECIFIC CIS REGULATORY ELEMENTS

Title (de)

VERFAHREN FÜR DIE IDENTIFIZIERUNG, CHARACTERISIERUNG UND VORTBILDUNG VON ZELL-TYPEN SPEZIFISCHE CIS REGULATORISCHE ELEMENTE

Title (fr)

PROCEDES POUR IDENTIFIER, CARACTERISER ET FAIRE EVOLUER DES ELEMENTS REGULATEURS A EFFET CIS SPECIFIQUE DE TYPE CELLULAIRE

Publication

EP 0977885 A1 (EN)

Application

EP 98906378 A

Priority

  • US 9802758 W
  • US 80066497 A

Abstract (en)

[origin: WO9836097A1] The invention provides methods for efficient and rapid identification of cis-acting nucleic acid sequences that act in a cell-type specific manner to stimulate or repress the expression of linked genes or other neighboring sequences. The invention also provides methods for evolving novel regulatory sequences by in vitro manipulation of naturally occurring or synthetic cis-acting nucleic acid sequences followed by screening and counterscreening steps. Furthermore, the invention provides methods for determining the mechanism by which cell-type specific cis regulatory sequences confer cell-type specific expression. Also provided are diagnostic methods based on the use of cell-type specific cis regulatory sequences.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C12N 15/64; C12N 15/85; C12Q 1/00

IPC 8 full level (invention and additional information)

C12N 15/10 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12N 15/1051 (2013.01); C12Q 1/6897 (2013.01)

Citation (search report)

See references of WO 9836097A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9836097 A1 19980820; AU 6161698 A 19980908; CA 2281016 A1 19980820; EP 0977885 A1 20000209; US 6623922 B1 20030923

INPADOC legal status

2004-03-03 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030902

2001-08-22 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010709

2000-08-30 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: KAMB, CARL, ALEXANDER

2000-02-09 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990902

2000-02-09 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE