Global Patent Index - EP 0977994 A1

EP 0977994 A1 2000-02-09 - METHOD FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEAR RECEPTOR LIGANDS

Title (en)

METHOD FOR THE IDENTIFICATION AND CHARACTERIZATION OF NUCLEAR RECEPTOR LIGANDS

Title (de)

METHODE ZUR IDENTIFIZIERUNG UND CHARAKTERISIERUNG VON LIGANDEN NUKLEÄRER REZEPTOREN

Title (fr)

METHODE D'IDENTIFICATION ET DE CARACTERISATION DES LIGANDS DES RECEPTEURS NUCLEAIRES

Publication

EP 0977994 A1 (EN)

Application

EP 98914486 A

Priority

  • US 9806672 W
  • US 84556797 A

Abstract (en)

[origin: WO9848281A1] The present invention is directed to a methodology to study the effect of ligands that can modulate functions of nuclear receptors, and specifically, their interaction with specific DNA or other transcription factors. These receptors play a major role in the cascade of inter and intracellular physiological and biochemical events. They generally have a modular construction which enables them to recognize and bind to certain DNA sequences, or binding elements, such as hormone response elements. Various ligands, such as hormones, affect this interaction. In accordance with the methodology presented herein, measurements of such interactions are taken in real time and kinetic pattern. This allows the user to identify and to characterize ligands that are able to affect a receptor's interaction with its binding element. Hence, the present invention provides a useful tool for the elucidation, and development of ligands that affect transcription of target genes, either directly or indirectly.

IPC 1-7 (main, further and additional classification)

G01N 33/74; C12Q 1/68

IPC 8 full level (invention and additional information)

G01N 33/543 (2006.01); C12M 1/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)

CPC (invention and additional information)

G01N 33/743 (2013.01)

Citation (search report)

See references of WO 9848281A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9848281 A1 19981029; AU 6883198 A 19981113; CA 2286761 A1 19981029; EP 0977994 A1 20000209; JP 2002507276 A 20020305

INPADOC legal status


2004-11-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040525

2004-01-02 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031114

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

2000-02-09 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991025

2000-02-09 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-02-09 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19991025;LT PAYMENT 19991025;LV PAYMENT 19991025;MK PAYMENT 19991025;RO PAYMENT 19991025;SI PAYMENT 19991025