Global Patent Index - EP 0979233 A4

EP 0979233 A4 2001-03-21 - METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES

Title (en)

METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES

Title (de)

VERFAHREN ZUR SYNTHESE VON OLIGONUKLEOTIDEN IN LÖSUNG

Title (fr)

SYNTHESE D'OLIGONUCLEOTIDES EN SOLUTION

Publication

EP 0979233 A4 (EN)

Application

EP 98918629 A

Priority

  • US 9808192 W
  • US 84382097 A

Abstract (en)

[origin: WO9847910A1] This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

IPC 1-7 (main, further and additional classification)

C07H 19/00; C07H 21/00; C07H 21/02; C07H 21/04; C07H 19/10; C07H 19/06; C07H 19/16; C07C 43/215; C07C 43/225; C07C 43/23; C07F 7/02

IPC 8 full level (invention and additional information)

C07H 19/00 (2006.01); C07H 19/04 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01)

CPC (invention and additional information)

C07H 19/04 (2013.01)

Citation (search report)

  • [Y] EP 0644196 A1 19950322 - CIBA GEIGY AG [CH]
  • [Y] WO 9422802 A1 19941013 - LAPORTE PLC [GB], et al
  • [X] WO 9111467 A1 19910808 - ISP INVESTMENTS INC [US]
  • [PX] WO 9714706 A1 19970424 - NEXSTAR PHARMACEUTICALS INC [US], et al
  • [E] WO 9830578 A1 19980716 - NEXSTAR PHARMACEUTICALS INC [US]
  • [E] WO 9830575 A1 19980716 - NEXSTAR PHARMACEUTICALS INC [US], et al
  • [XY] H. SELIGER: "Scale-up of oligonucleotide synthesis in: Protocols for oligonucleotides and analogs (Editior: S. Agrawal)", METHODS IN MOLECULAR BIOLOGY, vol. 20, 1993, pages 391 - 403, XP002157921
  • [X] CHEMICAL ABSTRACTS, vol. 89, no. 25, 1978, Columbus, Ohio, US; abstract no. 215211, MUKHAMADALIEV, N. ET AL.: "Tetrafurfuryloxysilane" page 577; column l; XP002157922 & SU 627134 A1 19781005 - MUKHAMADALIEV NEMATZHAN [SU], et al
  • [X] BATTEN, R.J. ET AL.: "Mew surface-coating materials: electron-beam curing of some silicone-containing acrylates", POLYMER, vol. 33, 1992, pages 3037 - 43, XP000941887
  • See also references of WO 9847910A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9847910 A1 19981029; AU 7152098 A 19981113; CA 2286320 A1 19981029; EP 0979233 A1 20000216; EP 0979233 A4 20010321; IL 132377 D0 20010319; JP 2001520660 A 20011030

INPADOC legal status


2003-06-25 [18W] WITHDRAWN

- Effective date: 20030429

2003-02-26 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030110

2001-03-21 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010206

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-03-14 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 07H 19/00 A, 7C 07H 21/00 B, 7C 07H 21/02 B, 7C 07H 21/04 B, 7C 07H 19/10 B, 7C 07H 19/06 B, 7C 07H 19/16 B, 7C 07C 43/215 B, 7C 07C 43/225 B, 7C 07C 43/23 B, 7C 07F 7/02 B

2000-04-12 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: PROLIGO L.L.C.

2000-02-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991118

2000-02-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE