EP 0979271 A1 20000216 - VASCULAR ADHESION PROTEIN-1 HAVING AMINE OXIDASE ACTIVITY
Title (en)
VASCULAR ADHESION PROTEIN-1 HAVING AMINE OXIDASE ACTIVITY
Title (de)
VASKULÄRES ADHESIONSPROTEIN-1MIT AMINOXIDASEAKTIVITÄT.
Title (fr)
PROTEINE-1 D'ADHESION VASCULAIRE A ACTIVITE MONOAMINE-OXYDASE
Publication
Application
Priority
- FI 9800429 W 19980522
- US 86243397 A 19970523
Abstract (en)
[origin: WO9853049A1] VAP-1 is an endothelial sialoglycoprotein whose cell surface expression is induced under inflammatory conditions. It has previously been shown to mediate the binding of recirculating lymphocytes to human peripheral lymph node vascular endothelial cells in an L-selectin independent fashion. A VAP-1 cDNA has been purified and shown to encode a type II transmembrane protein of 84.6 KD with a single transmembrane domain located at the very N-terminal end of the molecule. VAP-1 exists, in vivo, predominantly as a dimer of 170-180 KD. Six potential N-linked glycosylation sites are located in the extracellular domain, as are three putative O-glycosylation sites. VAP-1 has no significant similarity to any currently known adhesion molecules but has significant identity to the copper-containing amine oxidase family. Enzyme assays have defined VAP-1 as a membrane-bound amine oxidase. Thus, VAP-1 is a new type of adhesion molecule with dual functions. With the appropriate glycosylation, and in the correct inflammatory setting, VAP-1 expression on the lumenal endothelial cell surface in locations mediating lymphocyte adhesion allows it to function as an adhesion receptor involved in a novel mechanism of lymphocyte homing. Its primary function in other locations may depend on its inherent amine oxidase activity.
IPC 1-7
IPC 8 full level
C07K 14/435 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C07K 14/705 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/06 (2006.01); C12P 21/02 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP KR)
C07K 14/705 (2013.01 - EP); C12N 9/0012 (2013.01 - KR); C12N 9/0022 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9853049 A1 19981126; AU 742098 B2 20011220; AU 7531498 A 19981211; CA 2289903 A1 19981126; CN 1269829 A 20001011; EP 0979271 A1 20000216; HU P0002234 A2 20001028; HU P0002234 A3 20051128; JP 2001507238 A 20010605; KR 100533911 B1 20051206; KR 20010012920 A 20010226; NO 995725 D0 19991122; NO 995725 L 19991122; NZ 501118 A 20020828; PL 192459 B1 20061031; PL 337004 A1 20000731; RU 2204838 C2 20030520
DOCDB simple family (application)
FI 9800429 W 19980522; AU 7531498 A 19980522; CA 2289903 A 19980522; CN 98805369 A 19980522; EP 98922815 A 19980522; HU P0002234 A 19980522; JP 55001798 A 19980522; KR 19997010888 A 19991123; NO 995725 A 19991122; NZ 50111898 A 19980522; PL 33700498 A 19980522; RU 99128056 A 19980522