Global Patent Index - EP 0979311 A1

EP 0979311 A1 2000-02-16 - $i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES

Title (en)

$i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES

Title (de)

$i(IN VIVO)VERWENDUNG REKOMBINAGENISCHER OLIGONUKLEOBASEN ZUR KORREKTUR GENETISCHER DEFEKTE IN HEPATOZYTEN

Title (fr)

UTILISATION $i(IN VIVO) D'OLIGONUCLEOBASES RECOMBINAGENES POUR CORRIGER LES LESIONS GENETIQUES DES HEPATOCYTES

Publication

EP 0979311 A1 (EN)

Application

EP 98920930 A

Priority

  • US 9808834 W
  • US 4528897 P
  • US 5483797 P
  • US 6499697 P

Abstract (en)

[origin: WO9849350A1] The present invention concerns compositions and methods for the introduction of specific genetic changes in endogenous genes of the cells of an animal. The genetic changes are effected by oligonucleotides or oligonucleotide derivatives and analogs, which are generally less than about 100 nucleotides in length. The invention provides for macromolecular carriers, optionally incorporating ligands for clathrin coated pit receptors. In one embodiment the ligand is a lactose or galactose and the genetic changes are made in hepatocytes. By means of the invention up to 40 % of the copiies of a target gene have been changed in vitro. Repair of mutant genes having a Crigler-Najjar like phenotype and Hemophilia B phenotype were observed.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; A61K 48/00; C07H 21/04

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 9/107 (2006.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 7/00 (2006.01); A61P 7/04 (2006.01); C12N 15/10 (2006.01)

CPC (invention and additional information)

C12N 15/102 (2013.01); A61K 9/1075 (2013.01); A61K 9/1272 (2013.01)

Citation (search report)

See references of WO 9849350A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9849350 A1 19981105; WO 9849350 A8 20000525; AU 7365498 A 19981124; AU 749410 B2 20020627; CA 2288209 A1 19981105; CN 1268186 A 20000927; EP 0979311 A1 20000216; JP 2002511851 A 20020416; KR 20010020375 A 20010315; NZ 500694 A 20010928

INPADOC legal status


2003-05-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20021101

2000-07-26 [RTI1] TITLE (CORRECTION)

- Free text: IN VIVO USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES

2000-02-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991119

2000-02-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE