Global Patent Index - EP 0980368 A1

EP 0980368 A1 20000223 - 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS

Title (en)

3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS

Title (de)

3-(3-PYRROLIDINYL)-2(3H)-1,3,4-OXADIAZOLONDERIVATE UND IHRE VERWENDUNG ALS 5-HT4 LIGANDEN

Title (fr)

DERIVES DE 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE ET LEUR UTILISATION COMME LIGANDS 5-HT4

Publication

EP 0980368 A1 (FR)

Application

EP 98924365 A

Priority

  • FR 9800887 W
  • FR 9705539 A

Abstract (en)

[origin: FR2763068A1] The invention concerns compounds of general formula (I) in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group or OR1 and X1 together represent a group of formula -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O, or -O(CH2)3O-, X2 represents hydrogen, an amino group or a group of general formula -NHCO2R in which R represents an alkyl or phenylalkyl group, X3 represents hydrogen or a halogen, and R2 represents hydrogen or an alkyl, phenylalkyl or [(4-dimethylamino)piperidin-1-ylcarbonyl]alkyl group. The invention is applicable in therapy. Said compounds can be used for treating or preventing disorders in which 5-HT4 receptors are involved, whether in the central nervous, the gastrointestinal, the cardiovascular or the urinary system.

IPC 1-7

C07D 413/04; C07D 413/14; A61K 31/41; A61K 31/445

IPC 8 full level

A61K 31/4245 (2006.01); A61K 31/454 (2006.01); A61P 1/00 (2006.01); A61P 13/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01)

CPC (source: EP)

A61P 1/00 (2018.01); A61P 1/04 (2018.01); A61P 1/12 (2018.01); A61P 9/00 (2018.01); A61P 13/00 (2018.01); A61P 13/04 (2018.01); A61P 13/12 (2018.01); A61P 25/00 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01); A61P 43/00 (2018.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

FR 2763068 A1 19981113; FR 2763068 B1 19990604; AR 012657 A1 20001108; AT 252577 T 20031115; AU 7658898 A 19981127; DE 69819147 D1 20031127; DE 69819147 T2 20040729; EP 0980368 A1 20000223; EP 0980368 B1 20031022; JP 2002504897 A 20020212; JP 4242929 B2 20090325; TW 404947 B 20000911; US 6248757 B1 20010619; WO 9850381 A1 19981112

DOCDB simple family (application)

FR 9705539 A 19970506; AR P980102080 A 19980505; AT 98924365 T 19980504; AU 7658898 A 19980504; DE 69819147 T 19980504; EP 98924365 A 19980504; FR 9800887 W 19980504; JP 54777998 A 19980504; TW 87107034 A 19980505; US 40377999 A 19991104