Global Patent Index - EP 0980370 A1

EP 0980370 A1 2000-02-23 - 5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS

Title (en)

5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS

Title (de)

5-PHENYL-2(3H)-1,3,4-OXADIAZOLONDERIVATE UND IHRE VERWENDUNG ALS 5-HT4 LIGANDEN

Title (fr)

DERIVES DE 5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE ET LEUR UTILISATION COMME LIGANDS 5-HT4

Publication

EP 0980370 A1 (FR)

Application

EP 98924364 A

Priority

  • FR 9800886 W
  • FR 9705537 A
  • FR 9705538 A

Abstract (en)

[origin: WO9850383A1] The invention concerns compounds of general formula (I) in which R1 represents H, an alkyl or a cycloalkylmethyl, X1 represents H or an alkoxy, or OR1 and X1 together represent a -OCH2O-, -O(CH2)2-, -O(CH2)3-, O(CH2)2O- or -O(CH2)3O- group, X2 represents H, an amino group or a -NHCO2R group in which R represents an alkyl or a phenylalkyl, X3 represents H or a halogen, n represents number 0, 1, 2, or 3, and Het represents either a pyrrolidin-1-yl group, or a piperidin-1-yl group optionally substituted, or a 1H-hexahydroazepin-1-yl group, or an 8-azabicyclo{3.2.1}oct-8-yl group, or a 4-(phenylmethyl)piperazin-1-yl group, or a 4-methyl-hexahydro-1,4-diazepin-1-yl group, or a 1,2,3,4-tetrahydrisoquinolin-2-yl group, or a 1-azabicyclo{2.2.2}oct-3-yl group. The invention is applicable in therapy. Said compounds are useful for preventing disorders in which 5-HT4 receptors are involved, whether in the central nervous, the gastrointestinal, the cardiovascular or the urinary system.

IPC 1-7 (main, further and additional classification)

C07D 453/02; A61K 31/41; A61K 31/435; A61K 31/445; A61K 31/46; A61K 31/47; A61K 31/495; A61K 31/55; C07D 271/113; C07D 413/04; C07D 413/06; C07D 413/14; C07D 451/02

IPC 8 full level (invention and additional information)

C07D 405/14 (2006.01); A61K 31/4245 (2006.01); A61K 31/439 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 453/02 (2006.01)

CPC (invention and additional information)

C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 453/02 (2013.01)

Citation (search report)

See references of WO 9850383A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9850383 A1 19981112; WO 9850383 A8 19990422; AU 7658798 A 19981127; EP 0980370 A1 20000223; JP 2002504896 A 20020212

INPADOC legal status


2002-01-23 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20011129

2001-11-21 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20011009

2000-02-23 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991206

2000-02-23 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-02-23 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 19991206;LT PAYMENT 19991206;LV PAYMENT 19991206;MK PAYMENT 19991206;RO PAYMENT 19991206;SI PAYMENT 19991206