EP 0980370 A1 20000223 - 5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS
Title (en)
5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS
Title (de)
5-PHENYL-2(3H)-1,3,4-OXADIAZOLONDERIVATE UND IHRE VERWENDUNG ALS 5-HT4 LIGANDEN
Title (fr)
DERIVES DE 5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE ET LEUR UTILISATION COMME LIGANDS 5-HT4
Publication
Application
Priority
- FR 9800886 W 19980504
- FR 9705537 A 19970506
- FR 9705538 A 19970506
Abstract (en)
[origin: WO9850383A1] The invention concerns compounds of general formula (I) in which R1 represents H, an alkyl or a cycloalkylmethyl, X1 represents H or an alkoxy, or OR1 and X1 together represent a -OCH2O-, -O(CH2)2-, -O(CH2)3-, O(CH2)2O- or -O(CH2)3O- group, X2 represents H, an amino group or a -NHCO2R group in which R represents an alkyl or a phenylalkyl, X3 represents H or a halogen, n represents number 0, 1, 2, or 3, and Het represents either a pyrrolidin-1-yl group, or a piperidin-1-yl group optionally substituted, or a 1H-hexahydroazepin-1-yl group, or an 8-azabicyclo{3.2.1}oct-8-yl group, or a 4-(phenylmethyl)piperazin-1-yl group, or a 4-methyl-hexahydro-1,4-diazepin-1-yl group, or a 1,2,3,4-tetrahydrisoquinolin-2-yl group, or a 1-azabicyclo{2.2.2}oct-3-yl group. The invention is applicable in therapy. Said compounds are useful for preventing disorders in which 5-HT4 receptors are involved, whether in the central nervous, the gastrointestinal, the cardiovascular or the urinary system.
IPC 1-7
C07D 453/02; C07D 271/113; C07D 413/06; C07D 413/04; C07D 413/14; C07D 451/02; A61K 31/435; A61K 31/41; A61K 31/445; A61K 31/47; A61K 31/46; A61K 31/55; A61K 31/495
IPC 8 full level
A61K 31/4245 (2006.01); A61K 31/439 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 453/02 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 9/00 (2017.12); A61P 25/00 (2017.12); A61P 43/00 (2017.12); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 453/02 (2013.01)
Citation (search report)
See references of WO 9850383A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9850383 A1 19981112; WO 9850383 A8 19990422; AU 7658798 A 19981127; EP 0980370 A1 20000223; JP 2002504896 A 20020212
DOCDB simple family (application)
FR 9800886 W 19980504; AU 7658798 A 19980504; EP 98924364 A 19980504; JP 54777898 A 19980504