Global patent index - EP 0980430 A1

EP 0980430 A1 2000-02-23 - RECOMBINANT FRAGMENTS OF THE HUMAN ACETYLCHOLINE RECEPTOR AND THEIR USE FOR TREATMENT OF MYASTHENIA GRAVIS

Title (en)

RECOMBINANT FRAGMENTS OF THE HUMAN ACETYLCHOLINE RECEPTOR AND THEIR USE FOR TREATMENT OF MYASTHENIA GRAVIS

Title (de)

REKOMBINANTE FRAGMENTE DES MENSCHLICHEN ACETYLCHOLIN-REZEPTORS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON MYASTHENIA GRAVIS

Title (fr)

FRAGMENTS DE RECOMBINAISON DU RECEPTEUR D'ACETYLCHOLINE HUMAIN ET LEUR UTILISATION POUR TRAITER LA MYASTHENIE

Publication

EP 0980430 A1 (EN)

Application

EP 98919450 A

Priority

  • IL 9800211 W
  • IL 12079297 A

Abstract (en)

[origin: WO9850544A1] Polypeptides capable of modulating the autoimmune response of an individual to human acetylcholine receptor (hAChR), more particularly polypeptides corresponding entirely or partially to the extracellular domain of hAChR alpha -subunit, are useful in the diagnosis and treatment of myasthenia gravis. Preferred polypeptides are polypeptides corresponding to amino acid residues 1-121 or 122-210 of the hAChR alpha -subunit sequence, and polypeptides corresponding to amino acid residues 1-121, 1-210 or 1-205 of the hAChR alpha -subunit sequence in which is inserted, between amino acid residues 58 and 59, a sequence of 25 amino acid residues encoded by the p3A exon of the hAChR alpha -subunit gene, and fragments, analogs, fused, soluble and denatured forms thereof. DNA molecules encoding said polypeptides are also provided.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; C07K 14/705; C12N 1/21; C12N 15/70; G01N 33/53

IPC 8 full level (invention and additional information)

C07K 14/705 (2006.01); C12N 1/21 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/70571 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9850544A1

Designated contracting state (EPC)

CH DE ES FR GB IT LI

EPO simple patent family

WO 9850544 A1 19981112; AU 7230898 A 19981127; EP 0980430 A1 20000223; IL 120792 D0 19970930

INPADOC legal status

2005-06-08 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20041201

2003-07-23 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030605

2000-02-23 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991207

2000-02-23 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): CH DE ES FR GB IT LI