EP 0981362 A1 20000301 - METHODS OF ENHANCING FUNCTIONING OF THE UPPER GASTROINTESTINAL TRACT
Title (en)
METHODS OF ENHANCING FUNCTIONING OF THE UPPER GASTROINTESTINAL TRACT
Title (de)
METHODEN ZUR VERBESSERUNG DER WIRKUNG DES OBEREN GASTROINTESTINALTRAKTES
Title (fr)
METHODES PERMETTANT D'AMELIORER LE FONCTIONNEMENT DU TRACTUS GASTRO-INTESTINAL SUPERIEUR
Publication
Application
Priority
- CA 9800497 W 19980515
- GB 9715481 A 19970723
- US 4675497 P 19970516
- US 5950498 A 19980413
Abstract (en)
[origin: WO9852600A1] The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the upper gastrointestinal tract including the esophagus and stomach. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of the upper gastrointestinal tract. Thus, the invention provides methods of proliferating the upper gastrointestinal tract in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the upper gastrointestinal tract, including inflammatory diseases. GLP-2 stimulates the growth of upper gastrointestinal tissue when administered in conjunction with other peptide hormones. The invention further provides pharmaceutical compositions of GLP-2 with at least one other peptide hormone, methods of enhancing the growth of upper gastrointestinal tissue and of gastrointestinal disorders by increasing serum levels of GLP-2 and at least one other peptide hormone, an kits for performing the methods of the invention.
IPC 1-7
A61K 38/26; A61K 38/30; A61K 38/27; A61K 35/38; G01N 33/50; C12N 5/06; C12N 5/08
IPC 8 full level
A61K 45/00 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 38/26 (2006.01); A61K 38/27 (2006.01); A61K 38/30 (2006.01); A61P 1/04 (2006.01)
CPC (source: EP)
A61K 38/26 (2013.01); A61K 38/27 (2013.01); A61K 38/30 (2013.01); A61P 1/00 (2017.12); A61P 1/04 (2017.12)
C-Set (source: EP)
Citation (search report)
See references of WO 9852600A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9852600 A1 19981126; WO 9852600 A9 20000309; AT E253375 T1 20031115; AU 746633 B2 20020502; AU 7516398 A 19981211; BR 9808804 A 20010918; CA 2289652 A1 19981126; CA 2289652 C 20120228; CN 1264307 A 20000823; CN 1264307 B 20131030; DE 69819488 D1 20031211; DE 69819488 T2 20040826; DK 0981362 T3 20040315; EP 0981362 A1 20000301; EP 0981362 B1 20031105; ES 2210756 T3 20040701; HK 1030160 A1 20010427; JP 2002502369 A 20020122; JP 2009280598 A 20091203; JP 4699576 B2 20110615; MX PA99010523 A 20040901; PT 981362 E 20040331
DOCDB simple family (application)
CA 9800497 W 19980515; AT 98922546 T 19980515; AU 7516398 A 19980515; BR 9808804 A 19980515; CA 2289652 A 19980515; CN 98807330 A 19980515; DE 69819488 T 19980515; DK 98922546 T 19980515; EP 98922546 A 19980515; ES 98922546 T 19980515; HK 01101222 A 20010220; JP 2009171401 A 20090722; JP 54974198 A 19980515; MX 9910523 A 19980515; PT 98922546 T 19980515