EP 0981528 A1 20000301 - REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY
Title (en)
REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY
Title (de)
REGIOISOMERE BENZOTHIOPYRANOPYRIDINE MIT ANTITUMOR- AKTIVITÄT
Title (fr)
BENZOTHIOPYRANOPYRIDINES REGIOISOMERES A ACTIVITE ANTITUMORALE
Publication
Application
Priority
- US 9808398 W 19980428
- US 4497097 P 19970428
Abstract (en)
[origin: WO9849172A1] This invention is directed to benzothiopyrano [2,3-b]-, [3,2-b]- and [3,2-c]-pyridines substituted in the positions 6 and 9. The compounds of the invention have general formula (I) wherein: one of X, Y or Z is nitrogen (-N=), the others being carbon (-CH=); R' is selected from the group consisting of (C1-C4)alkyl, nitro or -NH-R1, wherein R1 is selected from the group consisting of -CO-CH2-NR2R3, (C1-C10)alkyl, (C2-C10)alkyl having one or two substituents selected from the group consisting of -OR4 and -NR2R3, (C2-C10)alkyl interrupted by one or two oxygen atoms or by one -NR5- group, and said (C2-C10)alkyl being optionally substituted by one or two hydroxy or -NR2R3 groups; R is selected in the group consisting of hydrogen, (C1-C10)alkyl, (C2-C10)alkyl having one or two substituents selected from the group consisting of -OR4 and -NR2R3, (C2-C10)alkyl interrupted by one or two oxygen atoms or by one -NR5- group, and said (C2-C10)alkyl being optionally substituted by one or two hydroxy or -NR2R3 groups. These compounds have antitumor activity against human leukemias and solid tumors sensitive to treatment with mitoxantrone and antitumor antibiotics, such as doxorubicin.
IPC 1-7
IPC 8 full level
C07D 495/04 (2006.01)
CPC (source: EP)
C07D 495/04 (2013.01)
Citation (search report)
See references of WO 9849172A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9849172 A1 19981105; AU 7162898 A 19981124; CA 2288274 A1 19981105; EP 0981528 A1 20000301
DOCDB simple family (application)
US 9808398 W 19980428; AU 7162898 A 19980428; CA 2288274 A 19980428; EP 98918764 A 19980428