Global Patent Index - EP 0981528 A1

EP 0981528 A1 2000-03-01 - REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY

Title (en)

REGIOISOMERIC BENZOTHIOPYRANOPYRIDINES HAVING ANTITUMOR ACTIVITY

Title (de)

REGIOISOMERE BENZOTHIOPYRANOPYRIDINE MIT ANTITUMOR- AKTIVITÄT

Title (fr)

BENZOTHIOPYRANOPYRIDINES REGIOISOMERES A ACTIVITE ANTITUMORALE

Publication

EP 0981528 A1 (EN)

Application

EP 98918764 A

Priority

  • US 9808398 W
  • US 4497097 P

Abstract (en)

[origin: WO9849172A1] This invention is directed to benzothiopyrano [2,3-b]-, [3,2-b]- and [3,2-c]-pyridines substituted in the positions 6 and 9. The compounds of the invention have general formula (I) wherein: one of X, Y or Z is nitrogen (-N=), the others being carbon (-CH=); R' is selected from the group consisting of (C1-C4)alkyl, nitro or -NH-R1, wherein R1 is selected from the group consisting of -CO-CH2-NR2R3, (C1-C10)alkyl, (C2-C10)alkyl having one or two substituents selected from the group consisting of -OR4 and -NR2R3, (C2-C10)alkyl interrupted by one or two oxygen atoms or by one -NR5- group, and said (C2-C10)alkyl being optionally substituted by one or two hydroxy or -NR2R3 groups; R is selected in the group consisting of hydrogen, (C1-C10)alkyl, (C2-C10)alkyl having one or two substituents selected from the group consisting of -OR4 and -NR2R3, (C2-C10)alkyl interrupted by one or two oxygen atoms or by one -NR5- group, and said (C2-C10)alkyl being optionally substituted by one or two hydroxy or -NR2R3 groups. These compounds have antitumor activity against human leukemias and solid tumors sensitive to treatment with mitoxantrone and antitumor antibiotics, such as doxorubicin.

IPC 1-7 (main, further and additional classification)

C07D 495/04; A61K 31/435

IPC 8 full level (invention and additional information)

C07D 495/04 (2006.01)

CPC (invention and additional information)

C07D 495/04 (2013.01)

Citation (search report)

See references of WO 9849172A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9849172 A1 19981105; AU 7162898 A 19981124; CA 2288274 A1 19981105; EP 0981528 A1 20000301

INPADOC legal status


2002-05-22 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20011101

2000-03-01 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991124

2000-03-01 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE