EP 0981606 A2 20000301 - METHOD AND CONSTRUCT FOR INHIBITION OF CELL MIGRATION
Title (en)
METHOD AND CONSTRUCT FOR INHIBITION OF CELL MIGRATION
Title (de)
VERFAHREN UND VEKTOR ZUR HEMMUNG DER ZELL-MIGRATION
Title (fr)
PROCEDE ET CONSTRUCTION POUVANT INHIBER UNE MIGRATION CELLULAIRE
Publication
Application
Priority
- EP 98923197 A 19980511
- EP 97201423 A 19970512
- NL 9800259 W 19980511
Abstract (en)
[origin: WO9851788A2] A recombinant nucleic acid molecule comprising a vector useful for transfection or transduction of mammalian cells, wherein said vector contains a nucleic acid insertion encoding an expressible hybrid polypeptide or protein which comprises a domain with a binding function and a domain with an effector function. The domain with a binding function may comprise a receptor binding domain, and the domain with an effector function may have enzymatic activity, in particular protease inhibitor activity. The vector may be a viral (e.g. adenovirus or retrovirus) or non-viral vector useful for transfection or transduction of mammalian cells. The nucleic acid insertion encoding an expressible hybrid polypeptide or protein may be under the control of a cell- or tissue-specific promoter. A process for preventing local proteolytic activity, extracellular matrix degradation, cell migration, cell invasion, or tissue remodeling, comprising transfecting or transducing the cells involved or cells in their environment with the recombinant nucleic acid molecule to obtain local expression of the hybrid polypeptide or protein encoded thereby. A process for producing the hybrid polypeptide or protein by transfecting or transducing mammalian cells with the recombinant nucleic acid molecule to obtain expression and optionally recovering the hybrid polypeptide or protein produced.
IPC 1-7
IPC 8 full level
C07K 14/485 (2006.01); C07K 14/81 (2006.01); C07K 19/00 (2006.01); C12N 9/72 (2006.01); C12N 15/09 (2006.01); C12N 15/62 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/485 (2013.01); C07K 14/8114 (2013.01); C07K 14/8117 (2013.01); C07K 14/8146 (2013.01); C12N 9/6459 (2013.01); C12Y 304/21069 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9851788A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9851788 A2 19981119; WO 9851788 A3 19990520; AU 7553698 A 19981208; CA 2289117 A1 19981119; EP 0981606 A2 20000301; JP 2001525669 A 20011211; NO 995564 D0 19991112; NO 995564 L 20000111; NZ 500656 A 20011130
DOCDB simple family (application)
NL 9800259 W 19980511; AU 7553698 A 19980511; CA 2289117 A 19980511; EP 98923197 A 19980511; JP 54907798 A 19980511; NO 995564 A 19991112; NZ 50065698 A 19980511