Global Patent Index - EP 0981642 A1

EP 0981642 A1 2000-03-01 - KAPPA B KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME

Title (en)

KAPPA B KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME

Title (de)

IkB-KINASE, UNTEREINHEITEN DAVON UND ANWENDUNG DERSELBEN

Title (fr)

KINASE INHIBITRICE DE NF-KAPPA B KAPPA B, SOUS-UNITES DE LA KINASE KAPPA B ET PROCEDES D'UTILISATION

Publication

EP 0981642 A1 (EN)

Application

EP 98908673 A

Priority

  • US 9803511 W
  • US 81013197 A
  • US 6147097 P

Abstract (en)

[origin: WO9837228A1] The present invention provides an isolated nucleic acid molecule encoding I kappa B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I kappa B) that inhibits the activity of the NF- kappa B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I kappa B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies. The invention further provides methods of substantially purifying an IKK complex, methods of identifying an agent that can alter the association of an IKK complex or an IKK catalytic subunit with a second protein, and methods of identifying proteins that can interact with an IKK complex or an IKK catalytic subunit.

IPC 1-7 (main, further and additional classification)

C12Q 1/48; C07K 5/06; C07K 16/40; C12N 9/12; C12N 15/54; C12N 15/63

IPC 8 full level (invention and additional information)

G01N 33/53 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 16/40 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/54 (2006.01); C12Q 1/48 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

G01N 33/6842 (2013.01); C07K 16/40 (2013.01); C12N 9/1205 (2013.01); C12Q 1/48 (2013.01); C12Y 207/1101 (2013.01); G01N 33/68 (2013.01); A61K 38/00 (2013.01); G01N 2333/9121 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9837228 A1 19980827; AU 6664698 A 19980909; AU 740622 B2 20011108; CA 2281955 A1 19980827; CA 2281955 C 20090908; EP 0981642 A1 20000301; EP 0981642 A4 20030319; JP 2001524813 A 20011204; JP 2008115164 A 20080522; JP 4125379 B2 20080730

INPADOC legal status


2008-06-11 [18R] REFUSED

- Effective date: 20080208

2004-02-04 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031219

2003-03-19 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20030131

2000-08-23 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KARIN, MICHAEL

2000-08-23 [RIN1] INVENTOR (CORRECTION)

- Inventor name: DIDONATO, JOSEPH, A.

2000-08-23 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ROTHWARF, DAVID, M.

2000-08-23 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HAYAKAWA, MAKIO

2000-08-23 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ZANDI, EBRAHIM, USC NORRIS COMP.CANCER CENTER

2000-03-01 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990921

2000-03-01 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE