EP 0981642 A4 20030319 - KAPPA B KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME
Title (en)
KAPPA B KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME
Title (de)
IkB-KINASE, UNTEREINHEITEN DAVON UND ANWENDUNG DERSELBEN
Title (fr)
KINASE INHIBITRICE DE NF-KAPPA B KAPPA B, SOUS-UNITES DE LA KINASE KAPPA B ET PROCEDES D'UTILISATION
Publication
Application
Priority
- US 9803511 W 19980223
- US 81013197 A 19970225
- US 6147097 P 19971009
Abstract (en)
[origin: WO9837228A1] The present invention provides an isolated nucleic acid molecule encoding I kappa B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I kappa B) that inhibits the activity of the NF- kappa B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I kappa B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies. The invention further provides methods of substantially purifying an IKK complex, methods of identifying an agent that can alter the association of an IKK complex or an IKK catalytic subunit with a second protein, and methods of identifying proteins that can interact with an IKK complex or an IKK catalytic subunit.
IPC 1-7
C12Q 1/48; C12N 9/12; C12N 15/63; C12N 15/54; C07K 5/06; C07K 16/40
IPC 8 full level
G01N 33/53 (2006.01); C07K 5/06 (2006.01); C07K 5/08 (2006.01); C07K 16/40 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/54 (2006.01); C12Q 1/48 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 11/06 (2018.01); A61P 19/02 (2018.01); A61P 29/00 (2018.01); A61P 31/04 (2018.01); C07K 16/40 (2013.01); C12N 9/1205 (2013.01); C12Q 1/48 (2013.01); C12Y 207/1101 (2013.01); G01N 33/68 (2013.01); G01N 33/6842 (2013.01); A61K 38/00 (2013.01); G01N 2333/9121 (2013.01)
Citation (search report)
- [E] WO 9808955 A1 19980305 - SIGNAL PHARM INC [US]
- [E] WO 9901542 A1 19990114 - TULARIK INC [US]
- [E] EP 0897009 A2 19990217 - SMITHKLINE BEECHAM PLC [GB]
- [XD] CONNELLY M A ET AL: "CHUK, A NEW MEMBER OF THE HELIX-LOOP-HELIX AND LEUCINE ZIPPER FAMILIES OF INTERACTING PROTEINS, CONTAINS A SERINE-THREONINE KINASE CATALYTIC DOMAIN", CELLULAR AND MOLECULAR BIOLOGY RESEARCH, vol. 41, no. 6, 1995, pages 537 - 549, XP002914743
- [PAD] REGNIER C H ET AL: "IDENTIFICATION AND CHARACTERIZATION OF AN IKAPPAB KINASE", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 90, no. 2, 25 July 1997 (1997-07-25), pages 373 - 383, XP002053258, ISSN: 0092-8674
- [AD] CHEN Z J ET AL: "SITE-SPECIFIC PHOSPHORYLATION OF IKAPPABALPHA BY A NOVEL UBIQUITINATION-DEPENDENT PROTEIN KINASE ACTIVITY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 84, 22 March 1996 (1996-03-22), pages 853 - 862, XP002037788, ISSN: 0092-8674
- See also references of WO 9837228A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9837228 A1 19980827; AU 6664698 A 19980909; AU 740622 B2 20011108; CA 2281955 A1 19980827; CA 2281955 C 20090908; EP 0981642 A1 20000301; EP 0981642 A4 20030319; JP 2001524813 A 20011204; JP 2008115164 A 20080522; JP 4125379 B2 20080730
DOCDB simple family (application)
US 9803511 W 19980223; AU 6664698 A 19980223; CA 2281955 A 19980223; EP 98908673 A 19980223; JP 2007260506 A 20071004; JP 53695398 A 19980223