EP 0981745 A1 20000301 - THE USE OF A BONE MORPHOGENETIC PROTEIN (BMP) RECEPTOR COMPLEX FOR SCREENING
Title (en)
THE USE OF A BONE MORPHOGENETIC PROTEIN (BMP) RECEPTOR COMPLEX FOR SCREENING
Title (de)
DIE VERWENDUNG VON BMP-PROTEIN-REZEPTOR KOMPLEXEN ZUR AUFFINDUNG VON SUBSTANZEN DIE ZELLULARE DIFFERENZIERUNG INDUZIEREN UND ZELLEN DIE MIT EINEM ACTIVIN-REZEPTR CO-TRANSFIZIERT SIND
Title (fr)
UTILISATION D'UN COMPLEXE RECEPTEUR DE PROTEINE MORPHOGENETIQUE OSSEUSE (BMP) A DES FINS DE SELECTION
Publication
Application
Priority
- US 9809519 W 19980513
- US 4676897 P 19970516
Abstract (en)
[origin: WO9852038A1] The present invention relates to the use of a type II receptor that is shared between activins and bone morphogenetic proteins, together with a bone morphogenetic protein type I receptor, for screening cellular differentiation actives. The invention further relates to cells comprising DNA coding for this receptor and to that DNA. The present invention relates to a method for determining whether a compound is capable of binding to a new BMP complex and whether a test compound produces a signal upon binding to this BMP receptor protein complex. The invention further relates to a method for determining the concentration of a BMP receptor ligand in a clinical sample using a new BMP complex. The invention further relates to a host cell co-transfected with an expression vector comprising a DNA sequence that codes for components of this complex, or soluble fragments thereof.
IPC 1-7
IPC 8 full level
G01N 33/566 (2006.01); C07K 14/705 (2006.01); C12N 5/00 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12Q 1/48 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
G01N 33/74 (2013.01); G01N 2333/51 (2013.01); G01N 2333/71 (2013.01); G01N 2500/00 (2013.01)
Citation (search report)
See references of WO 9852038A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9852038 A1 19981119; AU 7478298 A 19981208; CA 2290755 A1 19981119; EP 0981745 A1 20000301; IL 132922 A0 20010319; JP 2002510198 A 20020402
DOCDB simple family (application)
US 9809519 W 19980513; AU 7478298 A 19980513; CA 2290755 A 19980513; EP 98922179 A 19980513; IL 13292298 A 19980513; JP 54935398 A 19980513