Title (en)

REDUCTION OF AROMATIC HALOGENIDES

Title (de)

REDUKTION AROMATISCHER HALOGENIDE

Title (fr)

REDUCTION D'HALOGENURES AROMATIQUES

Publication

EP 0983215 A1 20000308 (DE)

Application

EP 98916623 A 19980430

Priority

• AT 9800112 W 19980430
• AT 86597 A 19970521

Abstract (en)

[origin: WO9852885A1] The invention relates to the reduction of (hetero)aromatic halogenides of general formula (I) Ar-Xn to compounds of general formula (II) Ar-Hn. To achieve this, a reduction agent is used, in particular a hydride reactant such as lithium aluminium hydride (LiAlH4) in the presence of oxygen, in particular in the form of an oxygen-inert gas mixture. Reduction in the presence of oxygen gives a good yield in short reaction times, even when working on a semi-industrial or industrial basis. Reduction using LiAlH4 in the presence of oxygen can also be used to reduce complicated heteroaromatic halogenides, for instance for reducing bromonarwedine ketone acetal to narwedine ketone acetal on an industrial scale.

IPC 1-7

C07B 31/00; C07D 491/10; C07D 307/00; C07D 223/00

IPC 8 full level

C07D 491/06 (2006.01); C07B 31/00 (2006.01); C07C 1/26 (2006.01); C07C 15/24 (2006.01); C07D 333/10 (2006.01); C07D 491/20 (2006.01)

CPC (source: EP KR)

C07B 31/00 (2013.01 - EP KR); C07C 1/26 (2013.01 - EP KR); C07D 333/10 (2013.01 - EP KR)

C-Set (source: EP)

C07C 1/26 + C07C 15/24

Citation (search report)

See references of WO 9852885A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9852885 A1 19981126; AT 405051 B 19990525; AT A86597 A 19980915; AU 7012798 A 19981211; BG 103880 A 20000630; BR 9809661 A 20000711; CA 2289992 A1 19981126; CN 1257467 A 20000621; EP 0983215 A1 20000308; HU P0004681 A2 20010428; JP 2001525828 A 20011211; KR 20010012795 A 20010226; NO 995494 D0 19991110; NO 995494 L 19991110; NZ 500733 A 20010330; PL 336906 A1 20000717; SK 158399 A3 20000711

DOCDB simple family (application)

AT 9800112 W 19980430; AT 86597 A 19970521; AU 7012798 A 19980430; BG 10388099 A 19991115; BR 9809661 A 19980430; CA 2289992 A 19980430; CN 98805275 A 19980430; EP 98916623 A 19980430; HU P0004681 A 19980430; JP 54968898 A 19980430; KR 19997010758 A 19991120; NO 995494 A 19991110; NZ 50073398 A 19980430; PL 33690698 A 19980430; SK 158399 A 19980430