Global patent index - EP 0983353 A1

EP 0983353 A1 2000-03-08 - METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER

Title (en)

METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER

Title (de)

VERFAHREN UND ZUSAMMENSETZUNGEN FÜR DIE DIAGNOSE UND BEHANDLUNG VON KREBS.

Title (fr)

PROCEDES ET COMPOSITIONS POUR LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER

Publication

EP 0983353 A1 (EN)

Application

EP 98908888 A

Priority

  • US 9804141 W
  • US 3998097 P

Abstract (en)

[origin: WO9839430A1] The present invention relates to a novel gene, CaSm, that is highly expressed in cancer tissues and cell lines, especially pancreatic cancer. The full length cDNA of CaSm encodes a protein of 133 amino acids. CaSm contains the two Sm motifs found in the common snRNP proteins, with the greatest homology to the Sm G protein (60 % similarity). The present invention further encompasses CaSm peptides, fusion proteins, host cell expression systems, antibodies to CaSm, antisense CaSM molecules, and compounds that modulate CaSm gene expression or CaSm activity. Antisense CaSm RNA is able to alter the transformed phenotype of pancreatic cancer cells by reducing their ability to form large colonies in soft agar when compared to untransfected cells. The present invention also encompasses methods for disease diagnosis, drug screening and the treatment of cancer.

IPC 1-7 (main, further and additional classification)

C12N 15/11; C07H 21/04; C07K 14/00; C12N 1/20; C12N 15/63; C12N 15/85

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61B 10/00 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

C07K 14/4702 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9839430A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9839430 A1 19980911; AU 6681098 A 19980922; AU 734289 B2 20010607; CA 2283394 A1 19980911; EP 0983353 A1 20000308; JP 2001514507 A 20010911; NZ 337755 A 20010727

INPADOC legal status

2004-05-19 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20031001

2000-03-08 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991004

2000-03-08 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE