EP 0983353 A1 20000308 - METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
Title (en)
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN FÜR DIE DIAGNOSE UND BEHANDLUNG VON KREBS.
Title (fr)
PROCEDES ET COMPOSITIONS POUR LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 9804141 W 19980304
- US 3998097 P 19970304
Abstract (en)
[origin: WO9839430A1] The present invention relates to a novel gene, CaSm, that is highly expressed in cancer tissues and cell lines, especially pancreatic cancer. The full length cDNA of CaSm encodes a protein of 133 amino acids. CaSm contains the two Sm motifs found in the common snRNP proteins, with the greatest homology to the Sm G protein (60 % similarity). The present invention further encompasses CaSm peptides, fusion proteins, host cell expression systems, antibodies to CaSm, antisense CaSM molecules, and compounds that modulate CaSm gene expression or CaSm activity. Antisense CaSm RNA is able to alter the transformed phenotype of pancreatic cancer cells by reducing their ability to form large colonies in soft agar when compared to untransfected cells. The present invention also encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
IPC 1-7
C12N 15/11; C12N 15/63; C12N 15/85; C12N 1/20; C07H 21/04; C07K 14/00
IPC 8 full level
A01K 67/027 (2006.01); A61B 10/00 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/4702 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9839430A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9839430 A1 19980911; AU 6681098 A 19980922; AU 734289 B2 20010607; CA 2283394 A1 19980911; EP 0983353 A1 20000308; JP 2001514507 A 20010911; NZ 337755 A 20010727
DOCDB simple family (application)
US 9804141 W 19980304; AU 6681098 A 19980304; CA 2283394 A 19980304; EP 98908888 A 19980304; JP 53870498 A 19980304; NZ 33775598 A 19980304