Title (en)

NEUROTROPHIC FACTOR RECEPTORS

Title (de)

NEUROTROPHEN FAKTOR REZEPTOREN

Title (fr)

RECEPTEURS DU FACTEUR NEUROTROPE

Publication

EP 0983354 A2 20000308 (EN)

Application

EP 98918805 A 19980427

Priority

• US 9808486 W 19980427
• US 86635497 A 19970530

Abstract (en)

[origin: WO9854213A2] The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention involves the cloning and characterization of receptors for GDNF. Nucleic acid and amino acid sequences are described for GDNFR protein products. A hydrophobic domain with the features of a signal peptide is found at the amino terminus, while a second hydrophobic domain at the carboxy terminus is involved in the linkage of the receptor to the cell membrane. The lack of a transmembrane domain and cytoplasmic region indicates that GDNFR requires one or more accessory molecules in order to mediate transmenbrane signaling. GDNFR mRNA is widely distributed in both nervous system and non-neural tissues, consistent with the similar distribution found for GDNF.

IPC 1-7

C12N 15/12; C07K 14/71; A61K 38/17; C07K 16/28

IPC 8 full level

A61K 9/48 (2006.01); A61K 9/51 (2006.01); A61K 35/74 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01); C07K 14/71 (2006.01); C07K 17/00 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/00 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/577 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 25/00 (2017.12); A61P 25/18 (2017.12); A61P 25/28 (2017.12); C07K 14/71 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9854213A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9854213 A2 19981203; WO 9854213 A3 19990107; AU 7165998 A 19981230; CA 2291608 A1 19981203; CA 2291608 C 20040413; EP 0983354 A2 20000308; JP 2002505576 A 20020219; ZA 984404 B 19981201

DOCDB simple family (application)

US 9808486 W 19980427; AU 7165998 A 19980427; CA 2291608 A 19980427; EP 98918805 A 19980427; JP 50067499 A 19980427; ZA 984404 A 19980525