EP 0983511 A1 20000308 - SENSORS FOR SUGARS AND OTHER METAL BINDING ANALYTES
Title (en)
SENSORS FOR SUGARS AND OTHER METAL BINDING ANALYTES
Title (de)
SENSOREN FUR ZUCKER UND ANDERE METALL-BINDENDE ANALYTE
Title (fr)
DETECTEURS DE SUCRES ET D'AUTRES ANALYTES SE LIANT A DES METAUX
Publication
Application
Priority
- US 9703654 W 19970303
- US 1275696 P 19960304
Abstract (en)
[origin: WO9733177A1] Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl<-> release is used. Methods for monitoring the concentrations of sugars and related molecules using the metal based sensors (20, 50, 70) are also disclosed.
IPC 1-7
IPC 8 full level
C12Q 1/00 (2006.01); G01N 33/66 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C12Q 1/006 (2013.01); G01N 33/66 (2013.01); G01N 33/68 (2013.01); G01N 2600/00 (2013.01); G01N 2650/00 (2013.01)
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9733177 A1 19970912; AU 2073897 A 19970922; EP 0983511 A1 20000308; EP 0983511 A4 20011205
DOCDB simple family (application)
US 9703654 W 19970303; AU 2073897 A 19970303; EP 97908968 A 19970303