Global patent index - EP 0983511 A1

EP 0983511 A1 2000-03-08 - SENSORS FOR SUGARS AND OTHER METAL BINDING ANALYTES

Title (en)

SENSORS FOR SUGARS AND OTHER METAL BINDING ANALYTES

Title (de)

SENSOREN FUR ZUCKER UND ANDERE METALL-BINDENDE ANALYTE

Title (fr)

DETECTEURS DE SUCRES ET D'AUTRES ANALYTES SE LIANT A DES METAUX

Publication

EP 0983511 A1 (EN)

Application

EP 97908968 A

Priority

  • US 9703654 W
  • US 1275696 P

Abstract (en)

[origin: WO9733177A1] Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl<-> release is used. Methods for monitoring the concentrations of sugars and related molecules using the metal based sensors (20, 50, 70) are also disclosed.

IPC 1-7 (main, further and additional classification)

G01N 33/66

IPC 8 full level (invention and additional information)

C12Q 1/00 (2006.01); G01N 33/66 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

G01N 33/68 (2013.01); C12Q 1/006 (2013.01); G01N 33/66 (2013.01); G01N 2600/00 (2013.01); G01N 2650/00 (2013.01)

Designated contracting state (EPC)

DE FR GB

EPO simple patent family

WO 9733177 A1 19970912; AU 2073897 A 19970922; EP 0983511 A1 20000308; EP 0983511 A4 20011205

INPADOC legal status

2003-03-26 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20021107

2002-06-12 [17Q] FIRST EXAMINATION REPORT

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- Effective date: 20020426

2002-06-12 [RIN1] INVENTOR (CORRECTION)

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- Inventor name: ARNOLD, FRANCES, H.

2002-06-12 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: GUAN, ZHIBIN

2002-06-12 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: CHEN, CHAO-TSEN

2002-06-12 [RIN1] INVENTOR (CORRECTION)

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- Inventor name: CHEN, GUOHUA

2001-12-05 [A4] SUPPLEMENTARY SEARCH REPORT

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- Effective date: 20011022

2001-12-05 [AK] DESIGNATED CONTRACTING STATES:

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- Designated State(s): DE FR GB

2000-03-08 [17P] REQUEST FOR EXAMINATION FILED

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- Effective date: 19980925

2000-03-08 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE FR GB