EP 0986538 A1 20000322 - METHOD FOR PRODUCING CHIRAL 3,4-DEHYDROPROLINES
Title (en)
METHOD FOR PRODUCING CHIRAL 3,4-DEHYDROPROLINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON CHIRALEN 3,4-DEHYDROPROLINEN
Title (fr)
PROCEDE DE FABRICATION DE 3,4-DEHYDROPROLINES CHIRALES
Publication
Application
Priority
- DE 19723473 A 19970604
- EP 9803284 W 19980602
Abstract (en)
[origin: US6166222A] PCT No. PCT/EP98/03284 Sec. 371 Date Dec. 1, 1999 Sec. 102(e) Date Dec. 1, 1999 PCT Filed Jun. 2, 1998 PCT Pub. No. WO98/55456 PCT Pub. Date Dec. 10, 1998The invention relates to a process for preparing chiral 3,4-dehydroproline compounds of formula (I), in which R, R' and R'' have the meanings given in the description. The invention is characterized by a pyrrolecarboxylic acid derivative compound of formula (II) reacted first with an alkali or alkaline earth metal in ammonia and then with an aqueous salt solution or a compound of formula (III) in which X is a leaving group to form the final chiral product compound.
IPC 1-7
IPC 8 full level
C07D 405/12 (2006.01); C07D 207/20 (2006.01); C07D 207/22 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR US)
C07D 207/20 (2013.01 - KR); C07D 207/22 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US)
Citation (search report)
See references of WO 9855456A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
US 6166222 A 20001226; AU 8335298 A 19981221; BR 9809726 A 20000711; CA 2291787 A1 19981210; CN 1259122 A 20000705; DE 19723473 A1 19981210; EP 0986538 A1 20000322; HU P0002772 A2 20001228; HU P0002772 A3 20010228; IL 132988 A0 20010319; JP 2002506430 A 20020226; KR 20010013342 A 20010226; MX 9910984 A 20000401; NO 995939 D0 19991203; NO 995939 L 19991203; WO 9855456 A1 19981210; ZA 984814 B 19991217
DOCDB simple family (application)
US 42493399 A 19991201; AU 8335298 A 19980602; BR 9809726 A 19980602; CA 2291787 A 19980602; CN 98805882 A 19980602; DE 19723473 A 19970604; EP 9803284 W 19980602; EP 98933585 A 19980602; HU P0002772 A 19980602; IL 13298898 A 19980602; JP 50148499 A 19980602; KR 19997011338 A 19991203; MX 9910984 A 19991129; NO 995939 A 19991203; ZA 984814 A 19980604