EP 0986539 A1 20000322 - DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES
Title (en)
DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES
Title (de)
DNA-BINDENDE PYRROL- UND IMIDAZOLPOLYAMIDDERIVATE
Title (fr)
DERIVES DE POLYAMIDES PYRROLE-IMIDAZOLE LIANT L'ADN
Publication
Application
Priority
- US 9806997 W 19980408
- US 4344497 P 19970408
- US 4344697 P 19970408
- US 4202297 P 19970406
- US 83752497 A 19970421
- US 85352297 A 19970508
- US 9712722 W 19970721
Abstract (en)
[origin: WO9849142A1] Novel small molecule polyamides of Formula (I) that specifically bind with subnanomolar affinity to any predetermined sequence in the human genome with potential use in molecular biology and human medicine are described. Further, the designed compounds which target the minor groove of B-form double helical DNA offer a general approach for the control of gene-expression. Simple rules are disclosed which provide for rational control of the DNA-binding sequence specificity of synthetic polyamides containing N-methylpyrrole and N-methylimidazole amino acids. A series of molecular templates for polyamide design are disclosed which provide for small molecules which recognize predetermined DNA sequences with affinities and specificities comparable to sequence specific DNA-binding proteins such as transcription factors.
IPC 1-7
IPC 8 full level
A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 47/48 (2006.01); A61P 43/00 (2006.01); C07D 207/34 (2006.01); C07D 233/90 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07K 5/078 (2006.01); C07K 7/04 (2006.01); C08G 69/00 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61K 47/645 (2017.07); A61P 43/00 (2017.12); C07D 207/34 (2013.01); C07D 233/90 (2013.01); C07D 403/14 (2013.01); C07K 5/06139 (2013.01); C07K 5/06182 (2013.01); C07K 7/04 (2013.01); C08G 69/00 (2013.01); C12Q 1/6839 (2013.01)
Citation (search report)
See references of WO 9849142A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9849142 A1 19981105; CA 2286232 A1 19981105; EP 0986539 A1 20000322; JP 2002515063 A 20020521
DOCDB simple family (application)
US 9806997 W 19980408; CA 2286232 A 19980408; EP 98918047 A 19980408; JP 54701098 A 19980408