Global Patent Index - EP 0986554 A1

EP 0986554 A1 2000-03-22 - SULFATE SALT OF AN HIV PROTEASE INHIBITOR HAVING AN IMPROVED ORAL ABSORPTION AND BIOAVAILABILITY

Title (en)

SULFATE SALT OF AN HIV PROTEASE INHIBITOR HAVING AN IMPROVED ORAL ABSORPTION AND BIOAVAILABILITY

Title (de)

SULFATSALZ EINES HIV PROTEASE INHIBITORS MIT VERBESSERTER ORALER ABSORPTION UND BIOVERFÜGBARKEIT

Title (fr)

SEL DE SULFATE D'UN INHIBITEUR DE PROTEASE DU VIH A ABSORPTION ORALE ET BIODISPONIBILITE AMELIOREES

Publication

EP 0986554 A1 (EN)

Application

EP 98923741 A

Priority

  • GB 9714320 A
  • US 9810633 W
  • US 4795097 P

Abstract (en)

[origin: WO9854178A1] This invention relates to a sulfate salt of an HIV protease inhibitor, Compound (A), which is useful in the treatment of AIDS, ARC or HIV infection in adults and children. More specifically, the invention provides a sulfate salt of the HIV protease inhibitor, Compound (A) having substantially improved solibility in dilute HC1 (gastric acid) solution which results in much greater oral absorption and bioavailability in animal models. Processes for making the sulfate salt of the particular HIV protease inhibitor compounds are also disclosed.

IPC 1-7 (main, further and additional classification)

C07D 405/06; A61K 31/34; A61K 31/495

IPC 8 full level (invention and additional information)

A61K 31/496 (2006.01); A61P 31/18 (2006.01); A61P 43/00 (2006.01); C07D 405/06 (2006.01)

CPC (invention and additional information)

C07D 405/06 (2013.01)

Citation (search report)

See references of WO 9854178A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9854178 A1 19981203; AU 730245 B2 20010301; AU 7595998 A 19981230; BG 103923 A 20000630; BR 9809498 A 20000620; CA 2291086 A1 19981203; CN 1257497 A 20000621; EA 199901095 A1 20000828; EE 9900543 A 20000615; EP 0986554 A1 20000322; HR P980283 A2 19990831; HU 0004621 A2 20020328; HU 0004621 A3 20020429; ID 23858 A 20000525; IL 132779 D0 20010319; IS 5240 A 19991109; JP 2000513747 A 20001017; JP 3267632 B2 20020318; KR 20010013042 A 20010226; NO 995822 A 20000128; NO 995822 D0 19991126; PE 75099 A1 19990811; PL 336847 A1 20000717; SK 163299 A3 20000711; TR 9902816 T2 20000221; TW 438799 B 20010607

INPADOC legal status


2004-08-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040206

2003-11-12 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030925

2000-03-22 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991229

2000-03-22 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-03-22 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT PAYMENT 19991229;LV PAYMENT 19991229;RO PAYMENT 19991229;SI PAYMENT 19991229