EP 0986554 A1 20000322 - SULFATE SALT OF AN HIV PROTEASE INHIBITOR HAVING AN IMPROVED ORAL ABSORPTION AND BIOAVAILABILITY

Title (en)

SULFATE SALT OF AN HIV PROTEASE INHIBITOR HAVING AN IMPROVED ORAL ABSORPTION AND BIOAVAILABILITY

Title (de)

SULFATSALZ EINES HIV PROTEASE INHIBITORS MIT VERBESSERTER ORALER ABSORPTION UND BIOVERFÜGBARKEIT

Title (fr)

SEL DE SULFATE D'UN INHIBITEUR DE PROTEASE DU VIH A ABSORPTION ORALE ET BIODISPONIBILITE AMELIOREES

Publication

EP 0986554 A1 20000322 (EN)

Application

EP 98923741 A 19980526

Priority

GB 9714320 A 19970707
US 9810633 W 19980526
US 4795097 P 19970529

Abstract (en)

[origin: WO9854178A1] This invention relates to a sulfate salt of an HIV protease inhibitor, Compound (A), which is useful in the treatment of AIDS, ARC or HIV infection in adults and children. More specifically, the invention provides a sulfate salt of the HIV protease inhibitor, Compound (A) having substantially improved solibility in dilute HC1 (gastric acid) solution which results in much greater oral absorption and bioavailability in animal models. Processes for making the sulfate salt of the particular HIV protease inhibitor compounds are also disclosed.

IPC 1-7

C07D 405/06; A61K 31/495; A61K 31/34

IPC 8 full level

A61K 31/496 (2006.01); A61P 31/18 (2006.01); A61P 43/00 (2006.01); C07D 405/06 (2006.01)

CPC (source: EP KR)

A61P 31/18 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 405/06 (2013.01 - EP KR)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9854178 A1 19981203; AU 730245 B2 20010301; AU 7595998 A 19981230; BG 103923 A 20000630; BR 9809498 A 20000620; CA 2291086 A1 19981203; CN 1257497 A 20000621; EA 199901095 A1 20000828; EE 9900543 A 20000615; EP 0986554 A1 20000322; HR P980283 A2 19990831; HU P0004621 A2 20020328; HU P0004621 A3 20020429; ID 23858 A 20000525; IL 132779 A0 20010319; IS 5240 A 19991109; JP 2000513747 A 20001017; JP 3267632 B2 20020318; KR 20010013042 A 20010226; NO 995822 D0 19991126; NO 995822 L 20000128; PE 75099 A1 19990811; PL 336847 A1 20000717; SK 163299 A3 20000711; TR 199902816 T2 20000221; TW 438799 B 20010607

DOCDB simple family (application)

US 9810633 W 19980526; AU 7595998 A 19980526; BG 10392399 A 19991124; BR 9809498 A 19980526; CA 2291086 A 19980526; CN 98805372 A 19980526; EA 199901095 A 19980526; EE P9900543 A 19980526; EP 98923741 A 19980526; HR P980283 A 19980528; HU P0004621 A 19980526; ID 991462 A 19980526; IL 13277998 A 19980526; IS 5240 A 19991109; JP 50079999 A 19980526; KR 19997011018 A 19991126; NO 995822 A 19991126; PE 00043298 A 19980528; PL 33684798 A 19980526; SK 163299 A 19980526; TR 9902816 T 19980526; TW 87107834 A 19980520