Title (en)

1,6-NAPHTHYRIDINE ANTI-CONVULSANTS

Title (de)

1,6-NAPHTHYRIDIN ANTIKONVULSIONSMITTEL

Title (fr)

ANTI-CONVULSIFS DE 1,6-NAPHTHYRIDINE

Publication

EP 0986559 A1 20000322 (EN)

Application

EP 98924476 A 19980529

Priority

• GB 9801575 W 19980529
• GB 9711257 A 19970530

Abstract (en)

[origin: WO9854184A1] Compounds of formula (I) and pharmaceutically acceptable salts thereof, where R<1> is hydrogen, C1-6 alkyl optionally substituted by hydroxy or C1-4 alkoxy, or C1-6 alkylphenyl; R<2> is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, C1-6 alkylO-, C1-6 alkylS-, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4 alkyl-, C1-6 alkenyl, C1-6 alkynyl, CF3, CF3O, CF3CO-, C1-6 alkylCO-, C3-6 cycloaklylCO-, C3-6 cycloalkyl-C1-4 alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4 alkyl-, or -NR<3>R<4> where R<3> is hydrogen or C1-4 alkyl, and R<4> is hydrogen, C1-4 alkyl, -CHO, -CO2C1-4 alkyl or -COC1-4 alkyl; or two R<2> groups form a saturated carbocyclic ring optionally interrupted by oxygen; and X is selected from hydrogen, halogen, cyano, alkyl and alkoxy; are useful in the treatment and prophylaxis of disorders treatable by anti-convulsants, e.g. epilepsy.

IPC 1-7

C07D 471/04; A61K 31/435

IPC 8 full level

A61K 31/4375 (2006.01); A61P 3/10 (2006.01); A61P 21/00 (2006.01); A61P 21/02 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 25/34 (2006.01); C07D 471/04 (2006.01)

CPC (source: EP US)

A61P 3/10 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 21/02 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 25/34 (2017.12 - EP); C07D 471/04 (2013.01 - EP US)

Citation (search report)

See references of WO 9854184A1

Designated contracting state (EPC)

BE CH DK ES FR GB IT LI NL

DOCDB simple family (publication)

WO 9854184 A1 19981203; CA 2291254 A1 19981203; EP 0986559 A1 20000322; GB 9711257 D0 19970730; JP 2002501517 A 20020115; US 6245778 B1 20010612

DOCDB simple family (application)

GB 9801575 W 19980529; CA 2291254 A 19980529; EP 98924476 A 19980529; GB 9711257 A 19970530; JP 50039099 A 19980529; US 42439999 A 19991123